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Age\u2010related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged &gt;60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase. Despite the importance of this \u2018epidemic\u2019 problem, the primary biochemical and molecular mechanisms underlying age\u2010related deficits in neuromuscular integrity and function have not been fully determined. Skeletal muscle generates reactive oxygen and nitrogen species (RONS) from a variety of subcellular sources, and age\u2010associated oxidative damage has been suggested to be a major factor contributing to the initiation and progression of muscle atrophy inherent with ageing. RONS can modulate a variety of intracellular signal transduction processes, and disruption of these events over time due to altered redox control has been proposed as an underlying mechanism of ageing. The role of oxidants in ageing has been extensively examined in different model organisms that have undergone genetic manipulations with inconsistent findings. Transgenic and knockout rodent studies have provided insight into the function of RONS regulatory systems in neuromuscular ageing. This review summarizes almost 30\u00a0years of research in the field of redox homeostasis and muscle ageing, providing a detailed discussion of the experimental approaches that have been undertaken in murine models to examine the role of redox regulation in age\u2010related muscle atrophy and weakness.<\/jats:p>","DOI":"10.1002\/jcsm.12223","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T01:08:41Z","timestamp":1501031321000},"page":"881-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Redox homeostasis and age\u2010related deficits in neuromuscular integrity and function"],"prefix":"10.1002","volume":"8","author":[{"given":"Giorgos K.","family":"Sakellariou","sequence":"first","affiliation":[{"name":"GeneFirst Ltd Culham Science Centre Abingdon Oxfordshire OX14 3DB UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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