{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:24:31Z","timestamp":1790497471408,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNAs (miRNA) are small non\u2010coding RNAs that target mRNAs and are consequently involved in the post\u2010transcriptional regulation of gene expression. Some miRNAs are ubiquitously expressed in tissue, while others are tissue\u2010specific or tissue\u2010enriched. miRNAs can be released by cells and are found in various biofluids, including serum and plasma. Thus, measuring miRNAs in the circulation may provide information on the originating tissue or cells. MyomiRs are described as striated muscle\u2010specific or muscle\u2010enriched miRNAs. Their circulating levels can be measured and have been proposed to be new biomarkers of physiological and pathological muscle processes. The aims of this review are to summarize the current knowledge of circulating myomiRs, to identify the types of information they can provide about skeletal muscle, and to determine how to apply that information in the fields of research and medicine.<\/jats:p>","DOI":"10.1002\/jcsm.12227","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:38:38Z","timestamp":1511969918000},"page":"20-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Circulating myomiRs: a new class of biomarkers to monitor skeletal muscle in physiology and medicine"],"prefix":"10.1002","volume":"9","author":[{"given":"Julien","family":"Siracusa","sequence":"first","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  1 place Val\u00e9rie Andr\u00e9, BP73, 91220 Br\u00e9tigny sur Orge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Koulmann","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  1 place Val\u00e9rie Andr\u00e9, BP73, 91220 Br\u00e9tigny sur Orge France"},{"name":"Ecole du Val de Gr\u00e2ce  1 place Alphonse Laveran, 75005 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Banzet","sequence":"additional","affiliation":[{"name":"Ecole du Val de Gr\u00e2ce  1 place Alphonse Laveran, 75005 Paris France"},{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  1 Rue Lieutenant Raoul Batany, 92140 Clamart France"},{"name":"INSERM UMRS1197  1 Rue Lieutenant Raoul Batany, 92140 Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3838"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.12.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.282"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.03.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1285"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209414109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.804508"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/cphy.c150041","article-title":"Regulation of skeletal muscle by microRNAs","author":"Diniz GP","year":"2016","journal-title":"Compr Physiol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2006.01.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710558105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602831103"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.06.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks466"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00080"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00075.2013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1152\/japplphysiol.00932.2006","article-title":"MicroRNA\u20101 and microRNA\u2010133a expression are decreased during skeletal muscle hypertrophy","volume":"102","author":"McCarthy JJ","year":"2006","journal-title":"J Appl Physiol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90562.2008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-254490"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114009","article-title":"Identification of microRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle","volume":"9","author":"Zacharewicz E","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.189860"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.255695"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.213363"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312467902"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01141.2013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.952663"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"H557","DOI":"10.1152\/ajpheart.00711.2013","article-title":"Circulating micrornas as potential biomarkers of aerobic exercise capacity","volume":"306","author":"Mooren FC","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125094","article-title":"Muscle releases alpha\u2010sarcoglycan positive extracellular vesicles carrying miRNAs in the bloodstream","volume":"10","author":"Guescini M","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.131797"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1397348"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12416"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100133"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018388","article-title":"Identification of muscle\u2010specific microRNAs in serum of muscular dystrophy animal models: promising novel blood\u2010based markers for muscular dystrophy","volume":"6","author":"Mizuno H","year":"2011","journal-title":"PLoS One"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2012.26","article-title":"Expression analysis in multiple muscle groups and serum reveals complexity in the microRNA transcriptome of the mdx mouse with implications for therapy","volume":"1","author":"Roberts TC","year":"2012","journal-title":"Mol Ther Nucleic Acids"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt724"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055281","article-title":"Distinctive serum miRNA profile in mouse models of striated muscular pathologies","volume":"8","author":"Vignier N","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.07.021"},{"key":"e_1_2_8_38_1","article-title":"Circulating muscle\u2010specific miRNAs in Duchenne muscular dystrophy patients","volume":"3","author":"Li X","year":"2014","journal-title":"Mol Ther Acids"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-014-0405-7"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2014.02.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080263","article-title":"Dystromirs as serum biomarkers for monitoring the disease deverity in Duchenne muscular dystrophy","volume":"8","author":"Zaharieva IT","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25174"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.495"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.01.007"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-14-7"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-5371"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.01.013"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22317"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90061-9"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00654.2015"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90218-3"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.08.015"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.10.025"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9342"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3029"},{"key":"e_1_2_8_56_1","first-page":"3097","article-title":"Decreased serum microRNA\u2010206 level predicts unfavorable prognosis in patients with melanoma","volume":"8","author":"Tian R","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27657"},{"key":"e_1_2_8_58_1","first-page":"4194","article-title":"Serum levels of microRNA\u2010133b and microRNA\u2010206 expression predict prognosis in patients with osteosarcoma","volume":"7","author":"Zhang C","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.424"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.002"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.030"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12082"},{"key":"e_1_2_8_63_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1373\/clinchem.2014.233338","article-title":"Taking it to the extreme: PCR at wittwerspeed","volume":"61","author":"Mackay JF","year":"2015","journal-title":"Clin Chem"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl416"},{"key":"e_1_2_8_65_1","article-title":"Ultrafast photonic PCR","volume":"4","author":"Son JH","year":"2015","journal-title":"Light Sci Appl"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.03.014"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2015.04.052"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14127"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-013-0114-x"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12089"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T14:02:33Z","timestamp":1695736953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jcsm.12227"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12227","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]},"assertion":[{"value":"2017-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}