{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:23:42Z","timestamp":1792592622257,"version":"4.5.0"},"reference-count":265,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T00:00:00Z","timestamp":1511049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The world population is ageing rapidly. As society ages, the incidence of physical limitations is dramatically increasing, which reduces the quality of life and increases healthcare expenditures. In western society, ~30% of the population over 55\u00a0years is confronted with moderate or severe physical limitations. These physical limitations increase the risk of falls, institutionalization, co\u2010morbidity, and premature death. An important cause of physical limitations is the age\u2010related loss of skeletal muscle mass, also referred to as sarcopenia. Emerging evidence, however, clearly shows that the decline in skeletal muscle mass is not the sole contributor to the decline in physical performance. For instance, the loss of muscle strength is also a strong contributor to reduced physical performance in the elderly. In addition, there is ample data to suggest that motor coordination, excitation\u2013contraction coupling, skeletal integrity, and other factors related to the nervous, muscular, and skeletal systems are critically important for physical performance in the elderly. To better understand the loss of skeletal muscle performance with ageing, we aim to provide a broad overview on the underlying mechanisms associated with elderly skeletal muscle performance. We start with a system level discussion and continue with a discussion on the influence of lifestyle, biological, and psychosocial factors on elderly skeletal muscle performance. Developing a broad understanding of the many factors affecting elderly skeletal muscle performance has major implications for scientists, clinicians, and health professionals who are developing therapeutic interventions aiming to enhance muscle function and\/or prevent mobility and physical limitations and, as such, support healthy ageing.<\/jats:p>","DOI":"10.1002\/jcsm.12238","type":"journal-article","created":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T00:08:36Z","timestamp":1511050116000},"page":"3-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":830,"title":["Skeletal muscle performance and ageing"],"prefix":"10.1002","volume":"9","author":[{"given":"Michael","family":"Tieland","sequence":"first","affiliation":[{"name":"Faculty of Sports and Nutrition Amsterdam University of Applied Sciences Dr. Meurerlaan 8 1067 SM Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez","family":"Trouwborst","sequence":"additional","affiliation":[{"name":"Faculty of Sports and Nutrition Amsterdam University of Applied Sciences Dr. Meurerlaan 8 1067 SM Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Clark","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute (OMNI) Ohio University 250 Irvine Hall Athens OH 45701 USA"},{"name":"Department of Biomedical Sciences Ohio University Athens OH 45701 USA"},{"name":"Department of Geriatric Medicine Ohio University Athens OH 45701 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Population Ageing and Development","author":"United 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