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While increases in circulating levels of a number of inflammatory cytokines have been associated with cancer cachexia, these associations were generally made in patients with advanced disease and thus may be associated with disease progression rather than directly with the cachexia syndrome. Thus, we sought to assess potential biomarkers of cancer\u2010induced cachexia in patients with earlier stages of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A custom multiplex array was used to measure circulating levels of 25 soluble factors from 70 pancreatic cancer patients undergoing attempted tumour resections. A high\u2010sensitivity multiplex was used for increased sensitivity for nine cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resectable pancreatic cancer patients with cachexia had low levels of canonical pro\u2010inflammatory cytokines including interleukin\u20106 (IL\u20106), interleukin\u20101\u03b2 (IL\u20101\u03b2), interferon\u2010\u03b3 (IFN\u2010\u03b3), and tumour necrosis factor (TNF). Even in our more sensitive analysis, these cytokines were not associated with cancer cachexia. Of the 25 circulating factors tested, only monocyte chemoattractant protein\u20101 (MCP\u20101) was increased in treatment\u2010na\u00efve cachectic patients compared with weight stable patients and identified as a potential biomarker for cancer cachexia. Although circulating levels of leptin and granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF) were found to be decreased in the same cohort of treatment\u2010na\u00efve cachectic patients, these factors were closely associated with body mass index, limiting their utility as cancer cachexia biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unlike in advanced disease, it is possible that cachexia in patients with resectable pancreatic cancer is not associated with high levels of classical markers of systemic inflammation. However, cachectic, treatment\u2010na\u00efve patients have higher levels of MCP\u20101, suggesting that MCP\u20101 may be useful as a biomarker of cancer cachexia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12251","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T04:22:02Z","timestamp":1515558122000},"page":"358-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Circulating monocyte chemoattractant protein\u20101 (MCP\u20101) is associated with cachexia in treatment\u2010na\u00efve pancreatic cancer patients"],"prefix":"10.1002","volume":"9","author":[{"given":"Erin E.","family":"Talbert","sequence":"first","affiliation":[{"name":"Arthur G. 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James Comprehensive Cancer Center Cancer Cachexia Program The Ohio State University  Columbus OH 43210 USA"},{"name":"Department of Surgery, Division of Surgical Oncology The Ohio State University  Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Farren","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology The Winship Cancer Institute of Emory University  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell L.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Arthur G. 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Fort Myers FL 33966 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology The Ohio State University  Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa A.","family":"Zimmers","sequence":"additional","affiliation":[{"name":"Department of Surgery Indiana University School of Medicine  Indianapolis IN 46202 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory B.","family":"Lesinski","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology The Winship Cancer Institute of Emory University  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Arthur G. 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