{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:28:31Z","timestamp":1793348911949,"version":"4.5.0"},"reference-count":87,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The concept of mitochondrial dysfunction in ageing muscle is highly controversial. In addition, emerging evidence suggests that reduced muscle oxidative capacity and efficiency underlie the aetiology of mobility loss in older adults. Here, we hypothesized that studying well\u2010phenotyped older cohorts across a wide range of physical activity would unveil a range of mitochondrial function in skeletal muscle and in turn allow us to more clearly examine the impact of age\n                      <jats:italic>per se<\/jats:italic>\n                      on mitochondrial energetics. This also enabled us to more clearly define the relationships between mitochondrial energetics and muscle lipid content with clinically relevant assessments of muscle and physical function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010nine volunteers were recruited to the following study groups: young active (YA,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02 women\/8 men, age\u00a0=\u00a031.2\u00a0\u00b1\u00a05.4\u00a0years), older active (OA,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02 women\/8 men, age\u00a0=\u00a067.5\u00a0\u00b1\u00a02.7\u00a0years), and older sedentary (OS,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08 women\/11 men, age\u00a0=\u00a070.7\u00a0\u00b1\u00a04.7\u00a0years). Participants completed a graded exercise test to determine fitness (VO\n                      <jats:sub>2<\/jats:sub>\n                      peak), a submaximal exercise test to determine exercise efficiency, and daily physical activity was recorded using a tri\u2010axial armband accelerometer. Mitochondrial energetics were determined by (i)\n                      <jats:sup>31<\/jats:sup>\n                      P magnetic resonance spectroscopy and (ii) respirometry of fibre bundles from\n                      <jats:italic>vastus lateralis<\/jats:italic>\n                      biopsies. Quadriceps function was assessed by isokinetic dynamometry and physical function by the short physical performance battery and stair climb test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Daily physical activity energy expenditure was significantly lower in OS, compared with YA and OA groups. Despite fitness being higher in YA compared with OA and OS, mitochondrial respiration, maximum mitochondrial capacity, Maximal AT\n                      <jats:styled-content>P<\/jats:styled-content>\n                      production\/\n                      <jats:styled-content>O<\/jats:styled-content>\n                      xygen consumption (P\/O) ratio, and exercise efficiency were similar in YA and OA groups and were significantly lower in OS. P\/O ratio was correlated with exercise efficiency. Time to complete the stair climb and repeated chair stand tests were significantly greater for OS. Interestingly, maximum mitochondrial capacity was related to muscle contractile performance and physical function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults who maintain a high amount of physical activity have better mitochondrial capacity, similar to highly active younger adults, and this is related to their better muscle quality, exercise efficiency, and physical performance. This suggests that mitochondria could be an important therapeutic target for sedentary ageing associated conditions including sarcopenia, dynapenia, and loss of physical function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12272","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T22:13:05Z","timestamp":1516831985000},"page":"279-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults"],"prefix":"10.1002","volume":"9","author":[{"given":"Giovanna","family":"Distefano","sequence":"first","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital  301 East Princeton Street Orlando FL 32804 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Standley","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital  301 East Princeton Street Orlando FL 32804 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital  301 East Princeton Street Orlando FL 32804 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvis A.","family":"Carnero","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital  301 East Princeton Street Orlando FL 32804 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanchao","family":"Yi","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital  301 East Princeton Street Orlando FL 32804 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather H.","family":"Cornnell","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital  301 East Princeton Street Orlando FL 32804 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Coen","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital  301 East Princeton Street Orlando FL 32804 USA"},{"name":"Sanford Burnham Prebys Medical Discovery Institute at Lake Nona  6400 Sanger Rd Orlando FL 32827 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.990S"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328337819e"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-015-0022-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12147"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb00986.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00844.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls196"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw059"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12568"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu134"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12418"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92143-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1044-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00125.2015"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(94)90061-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0349"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501559102"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-242750"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00282.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2012.02408.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1022-2"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.08.013"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010778"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.6.2033"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434040-00002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1219"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00628.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031986"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu086"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12139"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0068-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2006.01522.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.1.200"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.066"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.067314"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.048868"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr101"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00257.2014"},{"key":"e_1_2_8_43_1","volume-title":"ACSM's Guidlines for Exercise Testing and Prescription","author":"Thompson WRGN","year":"2010"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.045872"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019673"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.15.7396"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00459.2003"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0809"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37048"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90384.2008"},{"key":"e_1_2_8_52_1","first-page":"795","article-title":"On simple formulae for calculating the heat expenditure and the quantities of carbohydrate and fat oxidized in metabolism of men and animals, from gaseous exchange (Oxygen intake and carbonic acid output) and urine\u2010N","volume":"6","author":"Brouwer E","year":"1957","journal-title":"Acta Physiol Pharmacol Neerl"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00203.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31817c7133"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000012"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018317"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw102"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00135-2"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1085"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00587415"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01042285"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20381"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv169"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu086"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-0982OC"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.3.1072"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00566.2005"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.138362"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1139\/y91-084"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.4.1337"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/47.3.B71"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-014-9713-5"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1139\/h11-135"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.101691"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199207000-00008"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1969.26.5.644"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.004"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2007.01713.x"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610131104"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00203.x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.3.324"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601545200"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.12.1252"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.03.001"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.01.036"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3940"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12089"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:35:25Z","timestamp":1695544525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/jcsm.12272"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12272","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/164160","asserted-by":"object"}]},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,24]]},"assertion":[{"value":"2017-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}