{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:52:17Z","timestamp":1791917537133,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T00:00:00Z","timestamp":1519516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A multicentre study was conducted to investigate the impact of sarcopenia as an independent predictor of oncological outcome after radical cystectomy for bladder cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 500 patients with available digital computed tomography scans of the abdomen obtained within 90\u00a0days before surgery were identified. The lumbar skeletal muscle index was measured using pre\u2010operative computed tomography. Cancer\u2010specific survival (CSS) and overall survival (OS) were estimated using Kaplan\u2013Meier curves. Predictors of CSS and OS were analysed by univariable and multivariable Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on skeletal muscle index, 189 patients (37.8%) were classified as sarcopenic. Patients with sarcopenia were older compared with their counterparts (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), but both groups were comparable regarding to gender, comorbidity, tumor, node, metastasis (TNM) stage, and type of urinary diversion (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). In total, 234 (46.8%) patients died, and of these, 145 (29.0%) died because of urothelial carcinoma of the bladder. Sarcopenic patients had significantly worse 5\u00a0year OS (38.3% vs. 50.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and 5\u00a0year CSS (49.5% vs. 62.3%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016) rates compared with patients without sarcopenia. Moreover, sarcopenia was associated independently with both increased all\u2010cause mortality (hazard ratio, 1.43; 95% confidence interval 1.09\u20131.87; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and increased cancer\u2010specific mortality (hazard ratio, 1.42; 95% confidence interval, 1.00\u20132.02; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048). Our results are limited by the lack of prospective frailty assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia has been shown to be an independent predictor for OS and CSS in a large multicentre study with patients undergoing radical cystectomy for bladder cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12279","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T05:52:06Z","timestamp":1519624326000},"page":"505-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Sarcopenia as a comorbidity\u2010independent predictor of survival following radical cystectomy for bladder cancer"],"prefix":"10.1002","volume":"9","author":[{"given":"Roman","family":"Mayr","sequence":"first","affiliation":[{"name":"Department of Urology, St. Josef Medical Centre University of Regensburg  Landshuter Str. 65 Regensburg 93053 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