{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:31:26Z","timestamp":1791772286156,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01\u2010CA175011"],"award-info":[{"award-number":["R01\u2010CA175011"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R25\u2010CA092203"],"award-info":[{"award-number":["R25\u2010CA092203"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K99\u2010CA218603"],"award-info":[{"award-number":["K99\u2010CA218603"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Muscle abnormalities such as low muscle mass and low muscle radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is known in regard to the degree and impact of longitudinal changes in muscle mass and radiodensity within the context of cancer. Here, we explore the relationship between muscle wasting and mortality in a large population\u2010based study of patients with non\u2010metastatic colorectal cancer (CRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1924 patients with stage I\u2013III CRC who underwent surgical resection in the Kaiser Permanente Northern California Health System were included. Muscle mass and radiodensity were quantified using computed tomography images obtained at diagnosis and after approximately 14\u00a0months. Cox proportional\u2010hazards models were used to estimate hazard ratios for all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The hazard ratio for all\u2010cause mortality among patients with the largest deterioration in muscle mass (\u22652 SD; \u226511.4% loss from baseline), as compared with those who remained stable (\u00b11 SD; 0.0\u00a0\u00b1\u00a05.7%) was 2.15 [95% confidence interval (CI): 1.59\u20132.92;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001]. The hazard ratio for all\u2010cause mortality among patients who experienced the largest deterioration in muscle radiodensity (\u22652 SD; \u226520.2% loss from baseline), as compared with those who remained stable (\u00b11 SD; 0.0\u00a0\u00b1\u00a010.1%) was 1.61 (95% CI: 1.20\u20132.15;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with stage I\u2013III CRC, muscle wasting is a risk factor for mortality, independent of change in body mass and other body composition parameters.<\/jats:p>\n                  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H.","family":"Kroenke","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Castillo","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn L.","family":"Kwan","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M.","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Agricultural Food and Nutritional Science University of Alberta  Edmonton AB 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