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Peritumoural adipose tissue produces adipokines and angiogenic, apoptotic, and growth factors; given the possible crosstalk between the peritumoural adipose tissue and tumour, these may play an important role in cancer biology and carcinogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The aim of this study was to evaluate the factors produced by peritumoural adipose tissue in a cohort of 16 colorectal cancer patients with either weight\u2010stable cancer (WSC; <jats:italic>n<\/jats:italic>\u00a0=\u00a07) or CC (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). The study was approved by the Ethics Research Committee (972.914). Samples of peritumoural adipose tissue were analysed for concentrations of TNF\u2010\u03b1, IL\u20101\u03b2, STAT\u20101, STAT\u20103, RANTES, IL\u20101Ra, IP\u201010, IL\u201015, MCP\u20101, IFN\u2010\u03b1, GCSF, FADD, and TGF\u2010\u03b2. The cytokines and proteins were measured using Multiplex. Correlations between the proteins and cytokines were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TNF\u2010\u03b1, STAT\u20101, and FADD, a factor involved in apoptosis, were significantly higher in CC group than in the WSC group. In the peritumoural adipose tissue of the CC group, RANTES showed a significant positive correlation with IL\u20101Ra and IP\u201010 and a negative correlation with IFN\u2010\u03b1; and GCSF showed significant negative correlations with IL\u20101Ra, IP\u201010, IL\u201015, and MCP\u20101 and a positive correlation with IFN\u2010\u03b1. In the peritumoural adipose tissue of the WSC group, no significant correlations were detected between RANTES, GCSF, IL\u20103, FADD, and STAT\u20101 and the cytokines\/chemokines analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicated that inflammatory and tumorigenic pathways were altered in peritumoural adipose tissue in CC. Furthermore, inflammatory cytokines were correlated with growth factors in the peritumoural adipose tissue of cachectic patients, suggesting that inflammatory cytokines modulated the proliferative environment closely linked to the tumour.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12345","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T18:20:32Z","timestamp":1538763632000},"page":"1101-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Peritumoural adipose tissue pro\u2010inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patients"],"prefix":"10.1002","volume":"9","author":[{"given":"Nelson In\u00e1cio Pinto","family":"Neto","sequence":"first","affiliation":[{"name":"Escola Paulista de Medicina, Departamento de Fisiologia Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo 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