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The pathogenesis of primary sarcopenia is not completely understood. Herein, we review the essentials of the cellular and molecular mechanisms of skeletal mass maintenance; the alterations of myofiber metabolism and deranged properties of muscle satellite cells (the adult stem cells of skeletal muscles) that underpin the pathophysiology of primary sarcopenia; the role of the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010sensor protein, S100B, as an intracellular factor and an extracellular signal regulating cell functions; and the functional role of S100B in muscle tissue. Lastly, building on recent results pointing to S100B as to a molecular determinant of myoblast\u2013brown adipocyte transition, we propose S100B as a transducer of the deleterious effects of accumulation of reactive oxygen species in myoblasts and, potentially, myofibers concurring to the pathophysiology of sarcopenia.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.12363","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T04:36:12Z","timestamp":1543552572000},"page":"1255-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Cellular and molecular mechanisms of sarcopenia: the S100B perspective"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-3379","authenticated-orcid":false,"given":"Francesca","family":"Riuzzi","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia 06132 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