{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:19:13Z","timestamp":1787890753866,"version":"build-2784847793"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The associations between free\u2010living physical activity (PA) and sedentary behaviour (SB) and sarcopenia in older people and its determinants are controversial. Self\u2010reporting, the use of one\u2010size\u2010fits\u2010all cut\u2010points for intensity categorization when using accelerometers and the absence of a clear sarcopenia definition hampered explorations. The aim of this study is to describe the associations between objectively measured PA patterns and sarcopenia and its determinants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects aged &gt;65 with valid accelerometry and sarcopenia\u2010related measures from Toledo Study of Healthy Aging (TSHA) were included. Muscle mass (MM) was estimated by dual\u2010energy X\u2010ray absorptiometry. Handgrip strength (HS) was measured by dynamometry. Physical performance assessment relied on gait speed (GS). Sarcopenia presence was ascertained using Foundation for the National Institutes of Health (FNIH) criteria. PA and SB were estimated by ActiTrainer worn for 1\u00a0week and classified into time spent in SB and different PA intensity bands [light PA (LPA) and moderate\u2010to\u2010vigorous PA (MVPA)] using age\u2010specific cut\u2010points. Different multivariate linear and logistic regression models [(i) single\u2010parameter, (ii) partition, and (iii) isotemporal substitution models] were used for estimating associations between PA, SB, and sarcopenia determinants and sarcopenia rates, respectively. All models adjusted for age, sex, co\u2010morbidities (Charlson index), and functional ability (Katz and Lawton indexes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred twelve subjects from the TSHA had available data (78.08\u00a0\u00b1\u00a05.71\u00a0years of age; 54.3% women). FNIH sarcopenia assessment was performed in 497 subjects (23.3% were sarcopenic). In the linear regression, the single\u2010parameter model showed an association between MVPA and all sarcopenia determinants. In the partition model, MVPA was associated with greater MM and GS. The isotemporal substitution showed that reallocating 1\u00a0h\/day of MVPA displacing SB was associated with greater values in MM [<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.014; 95% confidence interval (CI)\u00a0=\u00a00.004, 0.024; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01], GS (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.082; 95% CI\u00a0=\u00a00.054, 0.110; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and HS (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.888; 95% CI\u00a0=\u00a00.145, 1.631; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In the logistic regression, the single\u2010parameter model yielded a significant association between 1\u00a0h\/day increase in MVPA and sarcopenia reduction [odds ratio (OR)\u00a0=\u00a00.522; 95% CI\u00a0=\u00a00.367, 0.726; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001], as did the partition model (OR\u00a0=\u00a00.555; 95% CI\u00a0=\u00a00.376, 0.799; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The reallocation of 1\u00a0h\/day SB only yielded a significant lower sarcopenia risk by almost 50% when it was substituted with MVPA, whereas the substitution of 15\u00a0min\/day yielded a significant lower sarcopenia risk by 15% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) but did not show any association when it was substituted with LPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An increase in MVPA replacing SB and LPA was associated with a reduction in sarcopenia prevalence and better performance across its determinants (MM, GS, and HS). LPA did not show any significant effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12369","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T15:30:26Z","timestamp":1553787026000},"page":"188-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Sedentary behaviour, physical activity, and sarcopenia among older adults in the TSHA: isotemporal substitution model"],"prefix":"10.1002","volume":"10","author":[{"given":"Juan Luis","family":"S\u00e1nchez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica Getafe University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asier","family":"Ma\u00f1as","sequence":"additional","affiliation":[{"name":"GENUD Toledo Research Group Universidad de Castilla\u2010La Mancha  Toledo Spain"},{"name":"CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"},{"name":"Geriatrics Department Virgen Del Valle Hospital  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ara","sequence":"additional","affiliation":[{"name":"GENUD Toledo Research Group Universidad de Castilla\u2010La Mancha  Toledo Spain"},{"name":"CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Carnicero","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica Getafe University Hospital  Madrid Spain"},{"name":"CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Walter","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica Getafe University Hospital  Madrid Spain"},{"name":"CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"},{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leocadio","family":"Rodr\u00edguez\u2010Ma\u00f1as","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica Getafe University Hospital  Madrid Spain"},{"name":"CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"},{"name":"Geriatrics Department Getafe University Hospital  Ctra. De Toledo Getafe Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.01.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00192"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2672435"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302501"},{"key":"e_1_2_8_6_1","first-page":"131","article-title":"Role of exercise on sarcopenia in the elderly","volume":"49","author":"Montero\u2010Fern\u00e1ndez N","year":"2013","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.2000.11082780"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys118"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-016-0658-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199805000-00021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000924"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318276c73c"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-382"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.17.1.17"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp163"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2013-093173"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-011-0075-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182399e5b"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0380-5"},{"key":"e_1_2_8_22_1","first-page":"63","article-title":"Quality control and data reduction procedures for accelerometry\u2010derived measures of physical activity","volume":"21","author":"Colley R","year":"2010","journal-title":"Health Rep"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90129-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12065"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60646-1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/aft063"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw090"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1424-8"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.10.013"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4126-x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.08.040"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12076"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt149"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116058"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/aft124"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2895-y"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13001"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.11.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu192"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.09.014"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20145"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls237"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.06.035"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.12.012"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-013-9586-z"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.12.010"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-017-0863-z"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821ece12"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.4.12.370"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.11.003"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000760"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.9.2.225"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e31815a51b3"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.18.2.158"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480410001725201"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0093-1"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-449"},{"key":"e_1_2_8_58_1","first-page":"280","article-title":"GT1M, GT3X and ActiTrainer counts comparison during standardized activities in young, adults and older adults","volume":"33","author":"Santos\u2010Lozano A","year":"2016","journal-title":"Nutr Hosp"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.2.378"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181eb6265"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0061-9"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200939010-00003"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.9.981"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52014.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12261"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:42:50Z","timestamp":1694371370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/jcsm.12369"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12369","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"2018-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}