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Muscle wasting leads to significant decrements in muscle strength, cardiorespiratory, and functional capacity, which increase mortality rates. As a consequence, different interventions have been tested to minimize muscle wasting. In this regard, blood flow restriction (BFR) has been used as a novel therapeutic approach to mitigate the burden associated with muscle waste conditions. Evidence has shown that BFR\n                    <jats:italic>per se<\/jats:italic>\n                    can counteract muscle wasting during immobilization or bed rest. Moreover, BFR has also been applied while performing low intensity resistance and endurance exercises and produced increases in muscle strength and mass. Endurance training with BFR has also been proved to increase cardiorespiratory fitness. Thus, frail patients can benefit from exercising with BFR due to the lower cardiovascular and join stress compared with traditional high intensity exercises. Therefore, low intensity resistance and endurance training combined with BFR may be considered as a novel and attractive intervention to counteract muscle wasting and to decrease the burden associated with this condition.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.12397","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:24:26Z","timestamp":1551313466000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Exercise with blood flow restriction: an effective alternative for the non\u2010pharmaceutical treatment for muscle wasting"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-7890","authenticated-orcid":false,"given":"Miguel S.","family":"Concei\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8547-419X","authenticated-orcid":false,"given":"Carlos","family":"Ugrinowitsch","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0025-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu123"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00704.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.04.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"e_1_2_7_7_1","first-page":"1635","article-title":"Validation of the consensus\u2010definition for cancer cachexia and evaluation of a classification model\u2014a study based on data from an international multicentre project (EPCRC\u2010CSA). 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