{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:37:36Z","timestamp":1792089456391,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Body weight loss is a frequent complication after stroke, and its adverse effect on clinical outcome has been shown in several clinical trials. The purpose of this prospective longitudinal single\u2010centre observational study was to investigate dynamical changes of body composition and body weight after ischemic stroke and an association with functional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven consecutive patients (age 69\u00a0\u00b1\u00a011\u00a0years, body mass index 27.0\u00a0\u00b1\u00a04.1\u00a0kg\/m<jats:sup>2<\/jats:sup>, 42% female patient, mean\u00a0\u00b1\u00a0SD) with acute ischemic stroke with mild to moderate neurological deficit (National Institute of Health Stroke Scale median 4, ranged 0\u201312) were analysed in the acute phase (4\u00a0\u00b1\u00a02\u00a0days) and at 12\u00a0months (389\u00a0\u00b1\u00a026\u00a0days) follow\u2010up. Body composition was examined by dual energy X\u2010ray absorptiometry. Cachexia was defined according to the consensus definition by body weight loss \u22655% within 1\u00a0year and additional clinical signs. Lean tissue wasting was considered if a ratio of upper and lower limbs lean mass sum to squared height (kg\/m<jats:sup>2<\/jats:sup>) was \u22645.45\u00a0kg\/m<jats:sup>2<\/jats:sup> for female patient and \u22647.25\u00a0kg\/m<jats:sup>2<\/jats:sup> for male patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the body weight changes after 12\u00a0months, 42 (63%) patients had weight gain or stable weight, 11 (16%) patients had moderate weight loss, and 14 (21%) patients became cachectic. A relative decline of 19% of fat tissue and 6.5% of lean tissue was observed in cachectic patients, while no changes of lean tissue were observed in non\u2010cachectic patients after 12\u00a0months. The modified Rankin Scale was 48% higher (2.1\u00a0\u00b1\u00a01.6, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), Barthel Index was 22% lower (71\u00a0\u00b1\u00a039, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and handgrip strength was 34% lower (21.9\u00a0\u00b1\u00a013.0, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in cachectic compared to non\u2010cachectic patients after 12\u00a0months.<\/jats:p><jats:p>The low physical performance if defined by Barthel Index &lt;60 points was linked to the lean tissue wasting (OR 44.8, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), presence of cachexia (OR 20.8, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and low body mass index &lt;25\u00a0kg\/m<jats:sup>2<\/jats:sup> (OR 11.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). After adjustment for cofounders, lean tissue wasting remained independently associated with the low physical performance at 12\u00a0months follow\u2010up (OR 137.9, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort study, every fifth patient with ischemic stroke fulfilled the criteria of cachexia within 12\u00a0months after index event. The incidence of cachexia was 21%. Cachectic patients showed the lowest functional and physical capacity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12400","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T05:12:51Z","timestamp":1548393171000},"page":"611-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Body weight changes and incidence of cachexia after stroke"],"prefix":"10.1002","volume":"10","author":[{"given":"Nadja","family":"Scherbakov","sequence":"first","affiliation":[{"name":"BIH Center for Regenerative Therapies (BCRT) Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  Germany"},{"name":"Department of Cardiology (Virchow Klinikum) Charit\u00e9 Universit\u00e4tsmedizin Berlin, and German Center for Cardiovascular Research (DZHK)  partner site Berlin Germany"},{"name":"Center for Stroke Research Berlin (CSB) Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  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