{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:37:11Z","timestamp":1789425431511,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Chugai Pharma France"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An international consensus proposed in 2011 a definition and classification system for cachexia (CAX), mainly based on weight loss, sarcopenia [skeletal muscle mass (SMM) loss], inflammation, and anorexia. The aim of this study was to stage CAX in non\u2010small\u2010cell lung cancer (NSCLC) patients by using a classification based on the Fearon criteria and supported by quantifiable parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional and non\u2010interventional multicentre study. SMM was assessed by analysing L3 computed tomography\u2010scan images. Patients completed the anorexia\/CAX subscale of the Functional Assessment of Anorexia\/Cachexia Therapy, EORTC QLQ\u2010C30 quality of life (QoL) and International Physical Activity Questionnaire (IPAQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were recruited in 56 sites. The analysis population comprised 531 patients, and SMM was assessed in 312 patients. Male patients were 66.5%, with a mean (SD) age of 65.2 (10.0) years, 79.9% were PS 0\u20131, and the tumour stage was mainly IIIB\u2010IV (87.3%). Overall, 38.7% of patients had CAX, 33.8% pre\u2010CAX, and 0.9% refractory CAX. Molecular tumour profiles were significantly associated with the presence of CAX: 23.9% in EGFR, ALK, ROS1, BRAF, or HER2+ patients, 41.4% in K\u2010RAS+, and 43.2% in patients with no molecular abnormality (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). The more advanced the CAX stage, the poorer the scores of functional items of the QoL (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and International Physical Activity Questionnaire (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Sarcopenia was present in 66.7% of CAX and 68.5% of pre\u2010CAX patients. Overall, 43.8% of pre\u2010CAX patients had only sarcopenia with limited weight loss (\u22642%) and no anorexia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to show the distribution of CAX in a population of NSCLC patients and an association between molecular abnormality in NSCLC and CAX. The original Fearon classification for CAX stages was supported by the associated functional QoL scores and physical activity levels, resulting in a clinically relevant system for detection of early stages of CAX.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12418","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:43:23Z","timestamp":1554119003000},"page":"782-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Staging of nutrition disorders in non\u2010small\u2010cell lung cancer patients: utility of skeletal muscle mass assessment"],"prefix":"10.1002","volume":"10","author":[{"given":"Sami","family":"Antoun","sequence":"first","affiliation":[{"name":"Emergency Unit, Gustave Roussy Paris Saclay University  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Morel","sequence":"additional","affiliation":[{"name":"Pneumology Department Centre Hospitalier R\u00e9gional d'Orleans  Orleans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Jean","family":"Souquet","sequence":"additional","affiliation":[{"name":"Pneumology Department Centre Hospitalier Lyon Sud  Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Surmont","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit Universitair Ziekenhuis Gent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Planchard","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institut Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Bonnetain","sequence":"additional","affiliation":[{"name":"Methodology and Quality of Life in Oncology Unit (EA 3181) Centre Hospitalier R\u00e9gional Universitaire de Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Foucher","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Centre Hospitalier Universitaire Dijon Bourgogne  Dijon Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Egenod","sequence":"additional","affiliation":[{"name":"Thoracic and Skin Oncology Unit Centre Hospitalier Universitaire De Limoges Dupuytren  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Krakowski","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Supportive care in Oncology (DISSPO\u2010CARE), French\u2010Speaking Association of Supportive Care in Cancer (AFSOS) Institut Bergoni\u00e9  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Chugai Pharma France Tour Franklin \u2010 Arche Sud  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Debieuvre","sequence":"additional","affiliation":[{"name":"GHRMSA, Pneumology Department, French College of General Hospital Respiratory Physicians (CPHG) H\u00f4pital Emile Muller  Mulhouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.3.1037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0272-5231(21)01147-3","article-title":"Lung cancer staging classification","volume":"14","author":"Mountain CF","year":"1993","journal-title":"Clin Chest Med"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(03)00077-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0033"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000690"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169136"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2997-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2016.09.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0058"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12206"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3795-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.28608C"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.01.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2826-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2722"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.1894"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.213"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.060228"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3282f9ae4d"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.05.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu086"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12200"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.09.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.062"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9730"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.05.001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109030"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev412"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101036"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.015"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2319"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12261"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T03:44:56Z","timestamp":1694317496000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/jcsm.12418"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12418","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2018-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}