{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:20:10Z","timestamp":1792704010944,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/08726\u20101"],"award-info":[{"award-number":["2016\/08726\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/50079\u20100"],"award-info":[{"award-number":["2012\/50079\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/04000\u20103"],"award-info":[{"award-number":["2016\/04000\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro\u2010environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis. The aim of the present study was to characterise the inflammatory circulating factors and tumour micro\u2010environment profile, as potentially contributing to tumour fibrosis in cachectic cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>74 patients (weight stable cancer <jats:italic>n<\/jats:italic> = 31; cachectic cancer <jats:italic>n<\/jats:italic> = 43) diagnosed with colorectal cancer were recruited, and tumour biopsies were collected during surgery.  Multiplex assay was performed to study inflammatory cytokines and growth factors. Immunohistochemistry analysis was carried out to study extracellular matrix components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher protein expression of inflammatory cytokines and growth factors such as epidermal growth factor, granulocyte\u2013macrophage colony\u2010stimulating factor, interferon\u2010\u03b1, and interleukin (IL)\u20108 was observed in the tumour and serum of cachectic cancer patients in comparison with weight\u2010stable counterparts. Also, IL\u20108 was positively correlated with weight loss in cachectic patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.627). Immunohistochemistry staining showed intense collagen deposition (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006) and increased presence of \u03b1\u2010smooth muscle actin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) in tumours of cachectic cancer patients, characterizing fibrosis. In addition, higher transforming growth factor (TGF)\u2010\u03b21, TGF\u2010\u03b22, and TGF\u2010\u03b23 expression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.047, respectively) was found in the tumour of cachectic patients, parallel to p38 mitogen\u2010activated protein kinase alteration. Hypoxia\u2010inducible factor\u20101\u03b1 mRNA content was significantly increased in the tumour of cachectic patients, when compared with weight\u2010stable group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate TGF\u2010\u03b2 pathway activation in the tumour in cachexia, through the (non\u2010canonical) mitogen\u2010activated protein kinase pathway. The results show that during cachexia, intratumoural inflammatory response contributes to the onset of fibrosis. Tumour remodelling, probably by TGF\u2010\u03b2\u2010induced transdifferentiation of fibroblasts to myofibroblasts, induces unbalanced inflammatory cytokine profile, angiogenesis, and elevation of extracellular matrix components (EMC). We speculate that these changes may affect tumour aggressiveness and present consequences in peripheral organs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12441","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T06:44:18Z","timestamp":1562309058000},"page":"1045-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Tumour\u2010derived transforming growth factor\u2010\u03b2 signalling contributes to fibrosis in patients with cancer cachexia"],"prefix":"10.1002","volume":"10","author":[{"given":"Joanna D.C.C.","family":"Lima","sequence":"first","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Simoes","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"de Castro","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mychel Raony P.T.","family":"Morais","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emidio M.","family":"de Matos\u2010Neto","sequence":"additional","affiliation":[{"name":"Department of Physical Education Federal University of Piau\u00ed  Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele J.","family":"Alves","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Pathology Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson I.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Physiology Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel G.","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telma M.T.","family":"Zorn","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alo\u00edsio S.","family":"Felipe\u2010Silva","sequence":"additional","affiliation":[{"name":"Service Pathological Anatomy University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Tokeshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 P.","family":"Otoch","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Department of Clinical Surgery University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda J.","family":"Cabral","sequence":"additional","affiliation":[{"name":"State University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emer S.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Laviano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia","family":"Seelaender","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Clinical Surgery University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-828"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/601434"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3292087"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00629"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/536954","article-title":"Inflammation in cachexia","volume":"2015","author":"Seelaender M","year":"2015","journal-title":"Mediators Inflamm"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000075"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.v17.i3.20"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3178-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216683282"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12037"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.10.039"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8018197"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00006.2017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.AM2017-LB-267","article-title":"Abstract LB\u2010267: metabolic alterations in tumors cause cachexia in pancreatic cancer","author":"Dasgupta A","year":"2017","journal-title":"Cancer Res"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.276733.115"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.841"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0054-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12345"},{"issue":"1","key":"e_1_2_10_22_1","article-title":"Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90","volume":"8","author":"Zhang G","year":"2017","journal-title":"Nature Communications"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.11.033"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201607052"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4318"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0217"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/1616781","article-title":"Reactive oxygen species and targeted therapy for pancreatic cancer","volume":"2016","author":"Zhang L","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011691"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801348115"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.10.008"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064465"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.05.006"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/587193"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2017.9"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.03.003"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.18632\/genesandcancer.130","article-title":"SPARC overexpression alters microRNA expression profiles involved in tumor progression","volume":"8","author":"Ahir BK","year":"2017","journal-title":"Genes Cancer"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6034"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"44534","DOI":"10.18632\/oncotarget.10003","article-title":"TGF\u2010\u03b21 contributes to CD8+ Treg induction through p38 MAPK signaling in ovarian cancer microenvironment","volume":"7","author":"Wu M","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.11.011"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600587444"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120502"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.12.59"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.2816"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1306363"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299694"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.3234"},{"key":"e_1_2_10_49_1","first-page":"27","article-title":"IL\u20108 secretion in primary cultures of prostate cells is associated with prostate cancer aggressiveness","volume":"6","author":"Neveu B","year":"2014","journal-title":"Res reports Urol"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-210"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.4035"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121140"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0028-x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.010"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0042-9"},{"key":"e_1_2_10_56_1","article-title":"A molecular portrait of epithelial\u2013mesenchymal plasticity in prostate cancer associated with clinical outcome","author":"Gleave ME","year":"2018","journal-title":"Oncogenesis"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i30.6764"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02173.x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.02.015"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415111112"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017010868"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6010005"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euprot.2015.06.004"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.441402"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.11.011"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.23.13955"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2013.17"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25492"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12441"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.437"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601913507951"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.285"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15422"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002830"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.5114\/ninp.2013.36757"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7993"},{"key":"e_1_2_10_77_1","first-page":"5376","article-title":"Enhanced expression of SPARC\/osteonectin in the tumor\u2010associated stroma of non\u2010small cell lung cancer is correlated with markers of hypoxia\/acidity and with poor prognosis of patients","volume":"63","author":"Koukourakis MI","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29055"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12261"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:00:14Z","timestamp":1694253614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/jcsm.12441"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12441","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,4]]},"assertion":[{"value":"2018-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}