{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:03:36Z","timestamp":1791475416536,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgen deprivation therapy (ADT) for prostate cancer (PCa) may prospectively decrease absolute lean mass (LM) and increase absolute fat mass (FM). Given that estimates of LM by dual\u2010energy X\u2010ray absorptiometry may be overestimated in obese people, this study examined the influence of adiposity on muscle health in men treated with ADT for PCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study examined the influence of adiposity on total and appendicular LM (ALM), muscle cross\u2010sectional (CSA), and muscle strength in 70 men treated with ADT [mean (standard deviation) age, 71 (6) years] for PCa compared with age\u2010matched PCa (<jats:italic>n<\/jats:italic>\u00a0=\u00a052) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a070). Total body LM, FM and ALM, and 66% tibia and radius muscle CSA were quantified by dual\u2010energy X\u2010ray absorptiometry and peripheral quantitative computed tomography, respectively. ALM was further divided by height (m<jats:sup>2<\/jats:sup>) or body mass index, with muscle CSA expressed as a per cent of total limb CSA. Upper and lower body and back (three\u2010repetition maximum and dynamometry) muscle strength were expressed per kilogram of body weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On average, ADT\u2010treated men had 4.4\u20136.4\u00a0kg greater FM compared with controls (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.014) and there were no differences in total body or ALM. Total body per cent LM and ALM<jats:sub>BMI<\/jats:sub> were 3.8\u20135.4% (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001) and 7.8\u20139.4% (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.001) lower, respectively, in ADT\u2010treated men compared with both controls. Percentage muscle CSA at both sites and muscle strength (except leg) were 3.0\u20136.0% (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.031) and 15\u201317% (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.010) lower, respectively, in ADT\u2010treated men compared with both controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings from this study indicate muscle mass, size, and strength are compromised in men treated with ADT after accounting for their increased adiposity or body size.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12446","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T14:43:38Z","timestamp":1557326618000},"page":"1036-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The clinical relevance of adiposity when assessing muscle health in men treated with androgen deprivation for prostate cancer"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-9375","authenticated-orcid":false,"given":"Patrick J.","family":"Owen","sequence":"first","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M.","family":"Daly","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Dalla Via","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh 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