{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:42:12Z","timestamp":1782168132801,"version":"3.54.5"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aging is associated with sarcopenia (low muscle mass) and dynapenia (low muscle strength) leading to disability and mortality. Widely used previous cut\u2010points for sarcopenia were established from dated, small, or pooled cohorts. We aimed to identify cut\u2010points of low strength as a determinant of impaired physical performance and cut\u2010points of low appendicular lean mass (ALM) as a predictor of low strength in a single, large, and contemporary cohort of community\u2010dwelling older adults and compare these criteria with others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional analyses were conducted on baseline data from 4725 and 4363 community\u2010dwelling men and women (65\u201386\u00a0years, 96.8% Caucasian) of the Canadian longitudinal study on aging comprehensive cohort. Physical performance was evaluated from gait speed, timed up\u2010and\u2010go, chair rise, and balance tests; a weighted\u2010sum score was computed using factor analysis. Strength was measured by handgrip dynamometry; ALM, by dual\u2010energy X\u2010ray absorptiometry and ALM index (ALMI; kg\/m<jats:sup>2<\/jats:sup>), was calculated. Classification and regression tree analyses determined optimal sex\u2010specific cut\u2010points of ALMI predicting low strength and of strength predicting impaired physical performance (score\u00a0&lt;\u00a01.5 SD below the sex\u2010specific mean).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Modest associations were found between ALMI and strength and between strength and physical performance score in both sexes. ALMI was not an independent predictor of physical performance score. Cut\u2010points of &lt;33.1 and &lt;20.4\u00a0kg were found to define dynapenia in men and in women, respectively, corresponding to 21.5% and 24.0% prevalence rates. Sarcopenia cut\u2010points were &lt;7.76\u00a0kg\/m<jats:sup>2<\/jats:sup> in men and &lt;5.72\u00a0kg\/m<jats:sup>2<\/jats:sup> in women; prevalence rates of 21.7% and 13.7%. Overall, 8.3% of men and 5.5% of women had sarco\u2010dynapenia. Sarcopenic were older and had lower fat mass and body mass index (BMI) than non\u2010sarcopenic participants. While the agreement between current criteria and the updated European Working Group for Sarcopenia in Older Persons recommendations was fair, we found only slight agreement with the Foundation for the National Institute of Health sarcopenia project. Older persons identified with sarcopenia as per the Foundation for the National Institute of Health criteria (using ALM\/BMI as the index) have higher BMI and fat mass compared with non\u2010sarcopenic and have normal ALMI as per our criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The proposed function\u2010derived cut\u2010points established from this single, large, and contemporary Canadian cohort should be used for the identification of sarcopenia and dynapenia in Caucasian older adults. We advise on using criteria based on ALMI in the diagnosis of sarcopenia. The modest agreement between sarcopenia and dynapenia denotes potential distinct health implications justifying to study both components separately.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12462","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T23:03:58Z","timestamp":1563231838000},"page":"985-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Physical function\u2010derived cut\u2010points for the diagnosis of sarcopenia and dynapenia from the Canadian longitudinal study on aging"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4551-1640","authenticated-orcid":false,"given":"Anne\u2010Julie","family":"Tessier","sequence":"first","affiliation":[{"name":"School of Human Nutrition McGill University  Sainte\u2010Anne\u2010de\u2010Bellevue Canada"},{"name":"Research Institute of the McGill University Health Centre  Montreal 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