{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:42:53Z","timestamp":1792629773129,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite no international consensus on the diagnostic criteria for sarcopenia, low lean mass, muscle strength, and physical function are important risk factors for disability, frailty, and mortality in older individuals, as well as in a wide range of patients with muscle loss. Here, we provide a population\u2010based reference material of total and regional lean body mass, muscle strength\/power parameters, and physical function in a healthy cohort of Danish men and women across the lifespan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Volunteers aged 20\u201393 years from the Copenhagen City Heart Study were invited to establish a Danish reference material (Copenhagen Sarcopenia Study) on lean mass characteristics [appendicular lean mass (ALM), iDXA, GE Lunar], muscle function [handgrip strength (HGS), Jamar dynamometer and leg extension power (LEP), Nottingham Power Rig], and physical function [30 s sit\u2010to\u2010stand test (STS), 10\u2010m maximal and habitual gait speed (GS)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1305 participants [729 women (age: 56.4 \u00b1 18.9 years, height: 1.66 \u00b1 0.01 m, body mass index: 24.6 \u00b1 4.3 kg\/m<jats:sup>2<\/jats:sup> and 576 men, age: 57.0 \u00b1 17.5 years, height: 1.80 \u00b1 0.07 m, body mass index: 26.0 \u00b1 3.9 kg\/m<jats:sup>2<\/jats:sup>] completed all measurements and were included in the present analysis. Lean mass characteristics (TLM, ALM, and ALM\/h<jats:sup>2<\/jats:sup>) decreased with increasing age in both men and women (<jats:italic>P<\/jats:italic> &lt; 0.001). Men demonstrated larger absolute and relative total ALM and higher HGS and LEP compared with women at all age intervals (<jats:italic>P<\/jats:italic> &lt; 0.001). HGS and LEP decreased progressively with age in both men and women (<jats:italic>P<\/jats:italic> &lt; 0.01); 30 s STS performance, habitual GS, and maximal GS decreased at an accellerated rate of decline with increasing age in both men and women (<jats:italic>P<\/jats:italic> &lt; 0.001). Habitual GS was reduced in men and women aged \u226570 years, while maximal GS was reduced from the age of \u226560 years compared with young adults (<jats:italic>P<\/jats:italic> &lt; 0.001). Regardless of sex, 30 s STS was reduced from the age of \u226550 years compared with the young reference group (<jats:italic>P<\/jats:italic> &lt; 0.001)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While the power\u2010based measurements (LEP and 30 s STS) started to decline already at age +50 years, less power\u2010based parameters (GS and HGS) and lean mass characteristics (TLM, ALM, and ALM\/h<jats:sup>2<\/jats:sup>) remained unaltered until after the age of +70 years. Notably, the cut\u2010off thresholds derived in the present study differed from earlier reference data, which underlines the importance of obtaining updated and local reference materials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12477","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:58:27Z","timestamp":1565960307000},"page":"1316-1329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":269,"title":["The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20\u201393 years"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-6508","authenticated-orcid":false,"given":"Charlotte","family":"Suetta","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet\u2010Glostrup Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Geriatric Research Unit, Geriatric Department Bispebjerg\u2010Frederiksberg University Hospital  Copenhagen Denmark"},{"name":"Geriatric Research Unit, Department of Internal Medicine Herlev\u2010Gentofte University Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Haddock","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet\u2010Glostrup Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Geriatric Research Unit, Geriatric Department Bispebjerg\u2010Frederiksberg University Hospital  Copenhagen Denmark"},{"name":"GENUD Toledo Research Group Universidad de Castilla\u2010La Mancha  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Noerst","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet\u2010Glostrup Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet\u2010Glostrup Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Ludvig","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet\u2010Glostrup Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Stefan","family":"Kamper","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet\u2010Glostrup Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Geriatric Research Unit, Geriatric Department Bispebjerg\u2010Frederiksberg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schnohr","sequence":"additional","affiliation":[{"name":"Copenhagen City Heart Study Bispebjerg\u2010Frederiksberg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Prescott","sequence":"additional","affiliation":[{"name":"Copenhagen City Heart Study Bispebjerg\u2010Frederiksberg University Hospital  Copenhagen Denmark"},{"name":"Department of Cardiology Bispebjerg\u2010Frederiksberg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars L.","family":"Andersen","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, Research Unit for Muscle Physiology and Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, Research Unit for Muscle Physiology and Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"B\u00fclow","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Bispebjerg\u2010Frederiksberg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hovind","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; 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