{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:41:06Z","timestamp":1790440866388,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n M\u00e9dica Mutua Madrile\u00f1a","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hip fracture is both a cause and a consequence of sarcopenia. Older persons with sarcopenia have an increased risk of falling, and the prevalence of sarcopenia may be increased in those who suffer a hip fracture. The aim of this study was to explore potential biomarkers (neuromuscular and peripheral pro\u2010inflammatory and oxidative stress markers) that may be associated with sarcopenia in very old persons with hip fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 150 consecutive patients \u226580 years old admitted to an orthogeriatric unit for an osteoporotic hip fracture. Muscle mass was assessed pre\u2010operatively using bioelectrical impedance analysis; Janssen's (J) and Masan\u00e9s' (M) reference cut\u2010off points were used to define low muscle mass. Muscle strength was assessed with handgrip strength (Jamar's dynamometer). Sarcopenia was defined by having both low muscle mass and strength and using the European Working Group on Sarcopenia in Older People 2 definition of probable sarcopenia (low grip strength). Peripheral markers\u2014pro\u2010inflammatory and oxidative stress parameters\u2014were determined either in the plasma or in the erythrocyte fraction obtained from peripheral whole blood of every patient pre\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 87.6 \u00b1 4.9 years, and 78.7% were women. The prevalence of sarcopenia was 11.5% with Janssen's, 34.9% with Masan\u00e9s' cut\u2010offs, and 93.3% with the European Working Group on Sarcopenia in Older People 2 definition of probable sarcopenia. Among the four pro\u2010inflammatory cytokines tested in plasma, only tumour necrosis factor\u2010\u03b1 was different (lower) in sarcopenic than in non\u2010sarcopenic participants using both muscle mass cut\u2010offs (J 7.9 \u00b1 6.2 vs. 8.3 \u00b1 5.8, M 6.8 \u00b1 4.7 vs. 9.1 \u00b1 6.2). Erythrocyte glutathione system showed a non\u2010significant tendency to lower glutathione levels and glutathione\/oxidized glutathione ratios in sarcopenic participants compared with non\u2010sarcopenic subjects. Catalase activity was also lower in sarcopenic participants (J 2904 \u00b1 1429 vs. 3329 \u00b1 1483, M 3037 \u00b1 1430 vs. 3431 \u00b1 1498). No significant differences were found between groups in chymotrypsin\u2010like activity of the 20S proteasome, superoxide dismutase, glutathione peroxidase and butyrylcholinesterase activity, C\u2010terminal agrin fragment, interferon\u2010\u03b3, or interleukin\u20101\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of sarcopenia in patients with hip fracture varies according to the definition and the muscle mass reference cut\u2010off points used. We did not find differences in most neuromuscular, pro\u2010inflammatory, or oxidative stress markers, except for lower peripheral tumour necrosis factor\u2010\u03b1 levels and catalase activity in sarcopenic participants, which may be markers of an early inflammatory reaction that is hampered in sarcopenic patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12508","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T09:45:23Z","timestamp":1578476723000},"page":"478-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Biomarkers of sarcopenia in very old patients with hip fracture"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-0518","authenticated-orcid":false,"given":"Carmen","family":"S\u00e1nchez\u2010Castellano","sequence":"first","affiliation":[{"name":"H. U. Ram\u00f3n y Cajal IRYCIS  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagrario","family":"Mart\u00edn\u2010Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda. Facultad de Farmacia. Universidad Complutense de Madrid.Departamento de Farmacolog\u00eda Universidad Complutense de Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Bermejo\u2010Besc\u00f3s","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda. Facultad de Farmacia. Universidad Complutense de Madrid.Departamento de Farmacolog\u00eda Universidad Complutense de Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Vaquero\u2010Pinto","sequence":"additional","affiliation":[{"name":"H. U. Ram\u00f3n y Cajal IRYCIS  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Miret\u2010Corchado","sequence":"additional","affiliation":[{"name":"Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Merello de Miguel","sequence":"additional","affiliation":[{"name":"H. U. Ram\u00f3n y Cajal IRYCIS  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso Jos\u00e9","family":"Cruz\u2010Jentoft","sequence":"additional","affiliation":[{"name":"H. U. 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