{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:06:17Z","timestamp":1792782377664,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Maastricht University Medical Centre","id":[{"id":"https:\/\/ror.org\/02d9ce178","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Limburg Kankerfonds"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Assessment of handgrip strength and fat\u2010free mass provides quick and objective information on muscle performance and mass that might complement subjective World Health Organization Performance Status (WHO PS). We investigated to what extent the presence of pre\u2010treatment handgrip weakness and low fat\u2010free mass index (FFMI) provides additional prognostic information on top of well\u2010established prognostic factors (including WHO PS) in non\u2010small cell lung cancer (NSCLC) patients selected for curative\u2010intent (chemo)radiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospectively, patients with early and locally advanced NSCLC (stages I\u2010III) treated with (chemo)radiation were enrolled. Handgrip weakness and low FFMI, derived from bioelectrical impedance analysis, were defined using normative values and were correlated with overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 936 patients (age 68 \u00b1 10 years; 64% male; 19% stage I, 9% stage II, and 72% stage III disease; 26% handgrip weakness; 27% low FFMI). In patients with good performance status (WHO PS 0 or 1), handgrip weakness and low FFMI were significant prognostic factors for OS, after adjustment for age, gender, disease stage, and co\u2010morbidities. The combined presence of handgrip weakness and low FFMI was a strong prognostic factor for OS when compared with patients with normal handgrip strength and FFMI (hazard ratio: 1.79, 95% confidence interval: 1.34\u20132.40,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). In patients with impaired performance status (WHO PS \u2265 2, 19% of sample), handgrip weakness and low FFMI were not related to OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In early and locally advanced NSCLC patients treated with curative\u2010intent (chemo)radiation who have good WHO PS, patients with combined handgrip weakness and low FFMI have the worst prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12526","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T11:40:34Z","timestamp":1581421234000},"page":"424-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Handgrip weakness, low fat\u2010free mass, and overall survival in non\u2010small cell lung cancer treated with curative\u2010intent radiotherapy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-8554","authenticated-orcid":false,"given":"Chris","family":"Burtin","sequence":"first","affiliation":[{"name":"REVAL\u2014Rehabilitation Research Center, BIOMED\u2014Biomedical Research Institute, Faculty of Rehabilitation Sciences Hasselt University  Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bezuidenhout","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MAASTRO Clinic) Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin J.C.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie C.","family":"Dingemans","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemie M.W.J.","family":"Schols","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie T.H.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MAASTRO Clinic) Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn A.","family":"Spruit","sequence":"additional","affiliation":[{"name":"REVAL\u2014Rehabilitation Research Center, BIOMED\u2014Biomedical Research Institute, Faculty of Rehabilitation Sciences Hasselt University  Diepenbeek Belgium"},{"name":"Department of Respiratory Medicine Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism  Maastricht The Netherlands"},{"name":"Department of Research &amp; Development CIRO  Horn, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk K.M.","family":"De Ruysscher","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (MAASTRO Clinic) Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"deaths by cause, age, sex, by country and by region, 2000\u20102016","author":"Global health estimates 2016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00664-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2162"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181da85e4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.09.026"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4563-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13640"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20777"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1894-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3148\/74.2.2013.69"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12181"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.06.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.479"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12383"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.10.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.7221"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.030"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2019.100154"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12487"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14769"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0261-5614(90)90035-Q"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12436"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3821-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207451"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2722"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-075"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2008.35"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-122"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.11.028"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2014.203"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12379"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12469"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12220"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12261"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcsm.12526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:35:23Z","timestamp":1694061323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,11]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/jcsm.12526"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12526","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,11]]},"assertion":[{"value":"2019-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}