{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:34:14Z","timestamp":1784327654122,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cachexia, a common manifestation of malignant cancer, is associated with wasting of skeletal muscle and fat tissue. In this study, we investigated the effects of a new first in class anabolic catabolic transforming agent on skeletal muscle in a rat model of cancer cachexia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Young male Wistar Han rats were intraperitoneally inoculated with 10<jats:sup>8<\/jats:sup> Yoshida hepatoma AH\u2010130 cells and once daily treated with 0.3 mg kg<jats:sup>\u22121<\/jats:sup>, 3 mg kg<jats:sup>\u22121<\/jats:sup> MT\u2010102, or placebo by gavage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three mg kg<jats:sup>\u22121<\/jats:sup>d<jats:sup>\u22121<\/jats:sup> MT\u2010102 not only prevented progressive loss of fat mass (\u22126 \u00b1 2 g vs \u201012 \u00b1 1 g; <jats:italic>P<\/jats:italic> &lt; 0.001); lean mass (+1 \u00b1 10 g vs. \u221237 \u00b1 2 g; <jats:italic>P<\/jats:italic> &lt; 0.001) and body weight (+1 \u00b1 13 g vs. \u221260 \u00b1 2 g; <jats:italic>P<\/jats:italic> &lt; 0.001) were remained. Quality of life was also improved as indicated by a higher food intake 12.9 \u00b1 3.1 g and 4.3 \u00b1 0.5 g, 3 mg kg<jats:sup>\u22121<\/jats:sup>d<jats:sup>\u22121<\/jats:sup> MT\u2010102 vs. placebo, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001) and a higher spontaneous activity (52 369 \u00b1 6521 counts\/24 h and 29 509 \u00b1 1775 counts\/24 h, 3 mg\u00b7kg<jats:sup>\u20101<\/jats:sup>d<jats:sup>\u20101<\/jats:sup> MT\u2010102 vs. placebo, respectively, <jats:italic>P<\/jats:italic> &lt; 0.01) on Day 11. Most importantly, survival was improved (HR = 0.29; 95% CI: 0.16\u20130.51, <jats:italic>P<\/jats:italic> &lt; 0.001). The molecular mechanisms behind these effects involve reduction of overall protein degradation and activation of protein synthesis, assessed by measurement of proteasome and caspase\u20106 activity or Western blot analysis, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study shows that 3 mg kg<jats:sup>\u22121<\/jats:sup> MT\u2010102 reduces catabolism, while inducing anabolism in skeletal muscle leading to an improved survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12537","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T06:30:04Z","timestamp":1582007404000},"page":"594-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["MT\u2010102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia"],"prefix":"10.1002","volume":"11","author":[{"given":"Mareike S.","family":"P\u00f6tsch","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Faculty of Medicine, Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Charite Medical School Berlin Institute of Health Center for Regenerative Therapies (BCRT)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Palus","sequence":"additional","affiliation":[{"name":"Charite Medical School Berlin Institute of Health Center for Regenerative Therapies (BCRT)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Tschirner","sequence":"additional","affiliation":[{"name":"Charite Medical School Berlin Institute of Health Center for Regenerative Therapies (BCRT)  Berlin 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