{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:23:09Z","timestamp":1790018589232,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article highlights preclinical and clinical studies in the field of wasting disorders that were presented at the 12th Cachexia Conference held in Berlin, Germany, in December 2019. Herein, we summarize the biological and clinical significance of different strategies including antibodies that target Fn14, Spsb 1, SAA1 treatment, ZIP14, a MuRF1 inhibitor, and new diagnostic tools like T\u2010cell communication targets and cut\u2010offs for the detection of skeletal muscle wasting. Of particular interest were the transplantation of mesenchymal stromal cells and muscle stem cell communication. Importantly, one presentation discussed the effect of metal ion transporter ZIP14 loss that reduces cancer\u2010induced cachexia. The potential of anti\u2010ZIP14 antibodies and zinc chelation as anti\u2010cachexia therapy may require testing in patients with cancer cachexia. Large clinical studies were presented such as RePOWER (observational study of patients with primary mitochondrial myopathy), MMPOWER (treatment with elamipretide in patients with primary mitochondrial myopathy), and ACT\u2010ONE as well as new mouse models like the KPP mouse. Promising treatments include rapamycin analogue treatment, anamorelin, elanapril, glucocorticoids, SAA1, antibodies that target Fn14, and a MuRF1 inhibitor. Clinical studies investigated novel approaches, including the role of exercise. It remains a fact, however, that effective treatments for cachexia and wasting disorders are urgently needed in order to improve patients' quality of life and their survival.<\/jats:p>","DOI":"10.1002\/jcsm.12552","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T16:09:47Z","timestamp":1581523787000},"page":"274-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Recent developments in the field of cachexia, sarcopenia, and muscle wasting: highlights from the 12th Cachexia Conference"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-594X","authenticated-orcid":false,"given":"Nicole","family":"Ebner","sequence":"first","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology (CVK) Charit\u00e9  Berlin Germany"},{"name":"Berlin\u2010Brandenburg Center for Regenerative Therapies (BCRT)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin, Charit\u00e9  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0061-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-014-0136-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12106"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12217"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0046-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.03.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx249"},{"key":"e_1_2_8_9_1","first-page":"1378","article-title":"Skeletal muscle mTORC1 regulates neuromuscular junction stability","volume":"10","author":"Baraldo M","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_10_1","first-page":"1378","article-title":"Feeding regulation of skeletal muscle 4E\u2010BP1 is disrupted in female tumour bearing mice initiating cachexia","volume":"10","author":"Counts BR","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"MuRF1 and MuRF2 are key players in skeletal muscle regeneration involving myogenic deficit and deregulation of the chromatin\u2010remodelling complex","volume":"2","author":"Moriscot AS","year":"2019","journal-title":"J Cachexia Sarco Muscle Rapid commu"},{"key":"e_1_2_8_12_1","first-page":"1378","article-title":"IL\u20101R inhibition reduced tumour growth, inflammation, and fibrosis in cachectic tumour bearing","volume":"10","author":"Lima JDCC","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_13_1","first-page":"1378","article-title":"Resveratrol inhibits body weight and skeletal muscle mass losses, decreases pro\u2010myogenic factors, decreases low\u2010degree systemic chronic inflammation, delays the onset of cachexia, and improves cancer\u2010related survival in C57BL\/6 mice bearing syngeneic tumour","volume":"10","author":"Cardoso\u2010Filho O","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_14_1","first-page":"1378","article-title":"Resveratrol negatively modulates pro\u2010adipogenic gene expression in visceral white adipose tissue of C57BL\/6 mice bearing syngeneic cutaneous melanoma","volume":"10","author":"Souza David LR","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_15_1","first-page":"1378","article-title":"F\u2010FDG PET imaging in pre\u2010clinical tumour\u2010bearing mouse models of cachexia suggests that Fn14 plays a role in glycolytic changes in the tumour occurring during cancer cachexia","volume":"10","author":"Burvenich IJ","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_16_1","first-page":"1378","article-title":"Mechanisms of tumour metabolic reprogramming by Fn14 as a driver of cancer cachexia","volume":"10","author":"Osellame LD","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.016"},{"key":"e_1_2_8_18_1","article-title":"Dual inhibition of MEK and PI3K\/Akt rescues cancer cachexia through both tumour extrinsic and intrinsic activities","volume":"3","author":"Talbert EE","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"e_1_2_8_19_1","first-page":"1","article-title":"Myostatin inhibitors as pharmacological treatment for muscle wasting and muscular dystrophy","volume":"2","author":"Saitoh M","year":"2017","journal-title":"J Cachexia Sarco Musc Cli Rep"},{"key":"e_1_2_8_20_1","first-page":"1378","article-title":"Generation of reporter cell lines to identify and characterize cachexia\u2010inducing factors","volume":"10","author":"Cao Z","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_21_1","first-page":"1378","article-title":"Small\u2010molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in tumour cachexia","volume":"10","author":"Adams V","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_22_1","first-page":"1378","article-title":"Spsb1 is involved in inflammation\u2010induced muscle atrophy","volume":"10","author":"Li Y","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_23_1","first-page":"1378","article-title":"Skeletal muscle and liver gene reprogramming during cancer cachexia in ApcMin\/+ mice: potential role of glucocorticoids","volume":"10","author":"Martin A","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_24_1","first-page":"1378","article-title":"Serum amyloid A1 mediates myotube atrophy via toll\u2010like receptors","volume":"10","author":"Hahn A","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_25_1","first-page":"1378","article-title":"Exploring the contribution of the liver to cancer cachexia development","volume":"10","author":"Molocea CE","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_26_1","first-page":"1","article-title":"High\u2010intensity interval training slows down tumour progression in mice bearing Lewis lung carcinoma","volume":"1","author":"Alves CRR","year":"2018","journal-title":"J Cachexia Sarco Muscle Ra Commu"},{"key":"e_1_2_8_27_1","first-page":"1378","article-title":"The mechanical stimulation of myotubes counteracts the effects of tumour\u2010derived factors through IL\u20104 secretion and the modulation of the activin\/follistatin ratio","volume":"10","author":"Coletti D","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_28_1","first-page":"1378","article-title":"SRF role as a mechano\u2010transductor in response to exercise in cancer cachexia","volume":"10","author":"Medhi H","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0054-2"},{"key":"e_1_2_8_30_1","first-page":"1378","article-title":"A subset of canonical Wnt and Hippo pathway transcriptional regulators ensure physiological synaptic gene transcription at the neuromuscular junction","volume":"10","author":"Hashemolhosseini S","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_31_1","first-page":"1","article-title":"Prevalence of sarcopenia in community\u2010dwelling older people of Mexico City using the EGWSOP (European Working Group on Sarcopenia in Older People) diagnostic criteria","volume":"2","author":"Espinel\u2010Berm\u00fadez MC","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle Clinical Reports"},{"key":"e_1_2_8_32_1","first-page":"1","article-title":"Sarcopenia: prevalence and prognostic implications in elderly patients with cardiovascular disease","volume":"2","author":"Kamiya K","year":"2017","journal-title":"J Cachexia Sarco Musc Cli Rep"},{"key":"e_1_2_8_33_1","first-page":"1","article-title":"Lean body mass, muscle fibre size and muscle function in cancer patients during chemotherapy and 10\u00a0weeks exercise","volume":"2","author":"L\u00f8nbro S","year":"2017","journal-title":"J Cachexia Sarco Musc Cli Rep"},{"key":"e_1_2_8_34_1","first-page":"1","article-title":"Low alanine transaminase is not associated with increased rate of mortality in patients with advanced lung cancer","volume":"2","author":"Dagan A","year":"2017","journal-title":"J Cachexia Sarco Musc Cli Rep"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108325076"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_8_40_1","first-page":"1378","article-title":"Sarcopenia as a mortality predictor in community\u2010dwelling older adults: a comparison of the diagnostic criteria of the European Working Group on Sarcopenia in Older People","volume":"10","author":"Bachettini NP","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_41_1","first-page":"1378","article-title":"Anthropometric muscle mass measurements, mid\u2010arm muscle, and calf\u2010circumference as a mortality predictor in obese and non\u2010obese older adults: Cohort Elderly Project\/Goiania","volume":"10","author":"Aparecida Silveira E","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_42_1","first-page":"1378","article-title":"A new diagnostic biomarker for cachexia: the role of serum creatinine\/cystatin C ratio","volume":"10","author":"Tsuneda T","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_43_1","first-page":"1378","article-title":"Comparison between sarcopenia and frailty as predictors of post\u2010operative complications: a cohort study","volume":"10","author":"Bicamumpaka Shema A","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_44_1","first-page":"1378","article-title":"CASC\u2010IN: a new tool to diagnose pre\u2010cachexia in cancer patients","volume":"10","author":"Busquets S","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0027-5"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00092"},{"key":"e_1_2_8_47_1","first-page":"1378","article-title":"Elevated plasma growth differentiation factor\u201015: a powerful prognostic factor that associates with skeletal muscle loss in patients with metastatic non\u2010small cell lung cancer","volume":"10","author":"Kazemi S","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2617-1619.2019.tb00012.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12316"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12379"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004389"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000743"},{"key":"e_1_2_8_53_1","article-title":"A mitochondrial targeting tetrapeptide Bendavia protects lateral line hair cells from gentamicin exposure","volume":"201","author":"Kuang X","journal-title":"J Appl Toxicol"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12423"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12501"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:53:34Z","timestamp":1693554814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jcsm.12552"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12552","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2020-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}