{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:38:37Z","timestamp":1788925117577,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lymphoma\/Leukemia Society Scholar Award for Clinical Research (Armenian) and National Institutes of Health\/National Cancer Institute","award":["CA196854"],"award-info":[{"award-number":["CA196854"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The number of patients undergoing autologous haematopoietic cell transplant (HCT) is growing, but little is known about the factors that predict adverse outcomes. Low muscle mass and obesity are associated with disability and premature mortality in individuals with non\u2010malignant diseases and may predict outcomes after autologous HCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of 320 patients who underwent autologous HCT for Hodgkin or non\u2010Hodgkin lymphoma between 2009 and 2014. Sarcopenia {skeletal muscle index male: &lt;43 cm\/m<jats:sup>2<\/jats:sup> [body mass index (BMI) &lt; 25 kg\/m<jats:sup>2<\/jats:sup>] or &lt; 53 cm\/m<jats:sup>2<\/jats:sup> [BMI \u2265 25 kg\/m<jats:sup>2<\/jats:sup>] and female: &lt;41 cm\/m<jats:sup>2<\/jats:sup> [regardless of BMI]) and obesity [total abdominal adiposity \u2265450.0 cm<jats:sup>2<\/jats:sup> (male), \u2265396.4 cm<jats:sup>2<\/jats:sup> (female)] were assessed from single\u2010slice abdominal pre\u2010HCT computed tomography images. Length of hospital stay, first unplanned intensive care unit admission, and 30\u2010day unplanned readmission were evaluated based on body composition using multivariable regression analysis, and mortality was evaluated with Kaplan\u2013Meier analysis and Gray's test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at HCT was 53.3 years (range, 18.5 to 78.1 years); 26.3% were sarcopenic and an additional 7.8% were sarcopenic obese pre\u2010HCT. Sarcopenic obesity was associated with increased risk of prolonged hospitalization [odds ratio (OR) = 3.6, 95% confidence interval (CI) 1.3\u20139.8], intensive care unit admission (OR = 4.7, 95% CI 1.5\u201316.1), and unplanned readmission after HCT (OR = 13.6, 95% CI 2.5\u201362.8). Patients who were sarcopenic obese also had the highest mortality risk at 1 year [hazard ratio (HR): 3.9, 95% CI 1.1\u201311.0] and 5 years (HR: 2.5, 95% CI 1.1\u20135.5), compared with patients with normal body composition. Sarcopenia alone, but not obesity alone, was associated with an increased risk of these outcomes, albeit with a lower magnitude of risk than in patients who were sarcopenic obese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenic obesity was an important predictor of outcomes in patients undergoing autologous HCT. These findings could inform targeted prevention strategies in patients at highest risk of complications after HCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12570","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T08:19:54Z","timestamp":1585124394000},"page":"962-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Abnormal body composition is a predictor of adverse outcomes after autologous haematopoietic cell transplantation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-8603","authenticated-orcid":false,"given":"Saro H.","family":"Armenian","sequence":"first","affiliation":[{"name":"Department of Population Sciences City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksi","family":"Iukuridze","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Berano","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine S.","family":"McCune","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine M.","family":"Zain","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sogol","family":"Mostoufi\u2010Moab","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana","family":"McCormack","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Slavin","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Department of Medicine Weill Cornell Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can\u2010Lan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Supportive Care Medicine City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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