{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:47:40Z","timestamp":1792666060911,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skeletal muscle wasting is an extremely common feature in patients with heart failure, affecting approximately 20% of ambulatory patients with even higher values during acute decompensation. Its occurrence is associated with reduced exercise capacity, muscle strength, and quality of life. We sought to investigate if the presence of muscle wasting carries prognostic information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred sixty\u2010eight ambulatory patients with heart failure (age 67.1\u00a0\u00b1\u00a010.9\u00a0years, New York Heart Association class 2.3\u00a0\u00b1\u00a00.6, left ventricular ejection fraction 39\u00a0\u00b1\u00a013.3%, and 21% female) were prospectively enrolled as part of the Studies Investigating Co\u2010morbidities Aggravating Heart Failure. Muscle wasting as assessed using dual\u2010energy X\u2010ray absorptiometry was present in 47 patients (17.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a mean follow\u2010up of 67.2\u00a0\u00b1\u00a028.02\u00a0months, 95 patients (35.4%) died from any cause. After adjusting for age, New York Heart Association class, left ventricular ejection fraction, creatinine, N\u2010terminal pro\u2010B\u2010type natriuretic peptide, and iron deficiency, muscle wasting remained an independent predictor of death (hazard ratio 1.80, 95% confidence interval 1.01\u20133.19,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04). This effect was more pronounced in patients with heart failure with reduced than in heart failure with preserved ejection fraction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Muscle wasting is an independent predictor of death in ambulatory patients with heart failure. Clinical trials are needed to identify treatment approaches to this co\u2010morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12603","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T01:30:59Z","timestamp":1596763859000},"page":"1242-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Muscle wasting as an independent predictor of survival in patients with chronic heart failure"],"prefix":"10.1002","volume":"11","author":[{"given":"Stephan","family":"von Haehling","sequence":"first","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Garfias Macedo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Valentova","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus S.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology and Berlin\u2010Brandenburg Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK), Partner Site Berlin Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin (CVK)  Berlin Germany"},{"name":"Department of Cardiology Charit\u00e9 Campus Benjamin Franklin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Ebner","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Bekfani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology and Angiology Magdeburg University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Haarmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg C.","family":"Schefold","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitja","family":"Lainscak","sequence":"additional","affiliation":[{"name":"Division of Cardiology General Hospital Murska Sobota  Murska Sobota Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G. F.","family":"Cleland","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics and Clinical Trials University of Glasgow  Glasgow UK"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology and Berlin\u2010Brandenburg Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK), Partner Site Berlin Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin (CVK)  Berlin Germany"},{"name":"BCRT\u2014Berlin Institute of Health Center for Regenerative Therapies Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Hasenfuss","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of 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