{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:22:19Z","timestamp":1792221739398,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Handgrip strength (HGS) is associated with poor clinical outcomes, including all\u2010cause, non\u2010cardiovascular, and cardiovascular mortalities. The published cut\u2010off points for HGS are mostly based on community populations from Western countries, lacking information on cancer patients from China. The objective of this study was to establish sex\u2010specific cut\u2010off points for Chinese cancer patients and investigate the effect of low HGS on cancer mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We did a retrospective cohort study of patients who were diagnosed with malignant cancer from June 2012 to December 2018. HGS was measured using a hand dynamometer in 8257 cancer patients. Optimal stratification was used to solve threshold points. The hazard ratio (HR) of all cancer mortality and cancer\u2010specific mortality was calculated using Cox proportional hazard regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among all participants, there were 3902 (47.3%) women and 4355 (52.7%) men. The median age was 58\u00a0years old. The cut\u2010off points of HGS to best classify patients with respect to time to mortality were &lt;16.1\u00a0kg for women and &lt;22\u00a0kg for men. Low HGS was associated with overall cancer mortality in both women and men [HR\u00a0=\u00a01.339, 95% confidence interval (CI)\u00a0=\u00a01.170\u20131.531,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; HR\u00a0=\u00a01.346, 95% CI\u00a0=\u00a01.176\u20131.540,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, respectively]. For specific cancer types, low HGS was associated with breast cancer (HR\u00a0=\u00a01.593, 95% CI\u00a0=\u00a01.230\u20132.063,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) in women, and lung cancer (HR\u00a0=\u00a01.369, 95% CI\u00a0=\u00a01.005\u20131.866,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.047) and colorectal cancer (HR\u00a0=\u00a01.399, 95% CI\u00a0=\u00a01.007\u20131.944,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.045) in men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>On the basis of our sex\u2010specific cut\u2010off points, low HGS was strongly associated with cancer mortalities. These results indicate the usefulness of HGS measurement in routine clinical practice for improving patient assessments, cancer prognosis, and intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12614","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T07:38:46Z","timestamp":1601019526000},"page":"1476-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Associations of low handgrip strength with cancer mortality: a multicentre observational study"],"prefix":"10.1002","volume":"11","author":[{"given":"Cheng\u2010Le","family":"Zhuang","sequence":"first","affiliation":[{"name":"Colorectal Cancer Center, Department of Gastrointestinal Surgery Shanghai Tenth People's Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Colorectal Cancer Center, Department of Gastrointestinal Surgery Shanghai Tenth People's Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center of the First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Institute of Gastroenterology The First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xia","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Daping Hospital &amp; Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, College of Public Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng\u2010Qing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fujian Cancer Hospital Fujian Medical University Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-8693","authenticated-orcid":false,"given":"Han\u2010Ping","family":"Shi","sequence":"additional","affiliation":[{"name":"Departments of Gastrointestinal Surgery and Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.6.2047"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2005.10.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu170"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0016-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt551"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121925"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2016-000097"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113637"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00246.2003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1010-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx497"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62000-6"},{"key":"e_1_2_8_16_1","first-page":"116","article-title":"The association between physical activity and risk of mortality is modulated by grip strength and cardiorespiratory fitness: evidence from 498 135 UK\u2010Biobank participants","volume":"38","author":"Celis\u2010Morales CA","year":"2016","journal-title":"Eur Heart J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx449"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1651"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000758"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl224"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7279"},{"key":"e_1_2_8_22_1","first-page":"41","volume-title":"Clinical Assessment Recommendations. 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