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They inhibit \u03b2\u2010hydroxy \u03b2\u2010methylglutaryl\u2010coenzyme A reductase, i.e. the rate\u2010limiting enzyme in mevalonate pathway, reduce endogenous cholesterol synthesis, and increase low\u2010density lipoprotein clearance by promoting low\u2010density lipoprotein receptor expression mainly in the hepatocytes. Statins have pleiotropic effects including stabilization of atherosclerotic plaques, immunomodulation, anti\u2010inflammatory properties, improvement of endothelial function, antioxidant, and anti\u2010thrombotic action. Despite all beneficial effects, statins may elicit adverse reactions such as myopathy. Studies have shown that mitochondria play an important role in statin\u2010induced myopathies. In this review, we aim to report the mechanisms of action of statins on mitochondrial function. Results have shown that statins have several effects on mitochondria including reduction of coenzyme Q10 level, inhibition of respiratory chain complexes, induction of mitochondrial apoptosis, dysregulation of Ca<jats:sup>2+<\/jats:sup> metabolism, and carnitine palmitoyltransferase\u20102 expression. The use of statins has been associated with the onset of additional pathological conditions like diabetes and dementia as a result of interference with mitochondrial pathways by various mechanisms, such as reduction in mitochondrial oxidative phosphorylation, increase in oxidative stress, decrease in uncoupling protein 3 concentration, and interference in amyloid\u2010\u03b2 metabolism.<\/jats:p><jats:p>Overall, data reported in this review suggest that statins may have major effects on mitochondrial function, and some of their adverse effects might be mediated through mitochondrial pathways.<\/jats:p>","DOI":"10.1002\/jcsm.12654","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T09:57:30Z","timestamp":1611914250000},"page":"237-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":241,"title":["Effects of statins on mitochondrial 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