{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:17:55Z","timestamp":1778822275750,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013465","name":"French Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The availability of non\u2010invasive, accessible, and reliable methods for estimating regional skeletal muscle volume is paramount in conditions involving primary and\/or secondary muscle wasting. This work aimed at (i) optimizing serial bioelectrical impedance analysis (S<jats:sub>BIA<\/jats:sub>) by computing a conductivity constant based on quantitative magnetic resonance imaging (MRI) data and (ii) investigating the potential of S<jats:sub>BIA<\/jats:sub> for estimating lean regional thigh muscle volume in patients with severe muscle disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty healthy participants with variable body mass index and 20 patients with idiopathic inflammatory myopathies underwent quantitative MRI. Anatomical images and fat fraction maps were acquired in thighs. After manual muscle segmentation, lean thigh muscle volume (lV<jats:sub>MRI<\/jats:sub>) was computed. Subsequently, multifrequency (50 to 350\u00a0kHz) serial resistance profiles were acquired between current skin electrodes (i.e. ankle and hand) and voltage electrodes placed on the anterior thigh. <jats:italic>In vivo<\/jats:italic> values of the muscle electrical conductivity constant were computed using data from S<jats:sub>BIA<\/jats:sub> and MRI gathered in the right thigh of 10 healthy participants. Lean muscle volume (lV<jats:sub>BIA<\/jats:sub>) was derived from S<jats:sub>BIA<\/jats:sub> measurements using this newly computed constant. Between\u2010day reproducibility of lV<jats:sub>BIA<\/jats:sub> was studied in six healthy participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Electrical conductivity constant values ranged from 0.82\u00a0S\/m at 50\u00a0kHz to 1.16\u00a0S\/m at 350\u00a0kHz. The absolute percentage difference between lV<jats:sub>BIA<\/jats:sub> and lV<jats:sub>MRI<\/jats:sub> was greater at frequencies &gt;270\u00a0kHz (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The standard error of measurement and the intra\u2010class correlation coefficient for lV<jats:sub>BIA<\/jats:sub> computed from measurements performed at 155\u00a0kHz (i.e. frequency with minimal difference) against lV<jats:sub>MRI<\/jats:sub> were 6.1% and 0.95 in healthy participants and 9.4% and 0.93 in patients, respectively. Between\u2010day reproducibility of lV<jats:sub>BIA<\/jats:sub> was as follows: standard error of measurement\u00a0=\u00a04.6% (95% confidence interval [3.2, 7.8] %), intra\u2010class correlation coefficient\u00a0=\u00a00.98 (95% confidence interval [0.95, 0.99]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrate a strong agreement of lean muscle volume estimated using S<jats:sub>BIA<\/jats:sub> against quantitative MRI in humans, including in patients with severe muscle wasting and fatty degeneration. S<jats:sub>BIA<\/jats:sub> shows promises for non\u2010invasive, fast, and accessible estimation and follow\u2010up of lean regional skeletal muscle volume for transversal and longitudinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12656","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T11:04:41Z","timestamp":1609326281000},"page":"39-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lean regional muscle volume estimates using explanatory bioelectrical models in healthy subjects and patients with muscle wasting"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-9916","authenticated-orcid":false,"given":"Damien","family":"Bachasson","sequence":"first","affiliation":[{"name":"Institute of Myology Neuromuscular Investigation Center, Neuromuscular Physiology and Evaluation Laboratory  Paris 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Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0777-2711","authenticated-orcid":false,"given":"Harmen","family":"Reyngoudt","sequence":"additional","affiliation":[{"name":"Institute of Myology Neuromuscular Investigation Center, NMR Laboratory  Paris France"},{"name":"CEA, DRF, IBFJ, MIRCen, NMR Laboratory  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-647X","authenticated-orcid":false,"given":"Benjamin","family":"Marty","sequence":"additional","affiliation":[{"name":"Institute of Myology Neuromuscular Investigation Center, NMR Laboratory  Paris France"},{"name":"CEA, DRF, IBFJ, MIRCen, NMR Laboratory  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-6927","authenticated-orcid":false,"given":"Pierre 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