{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:11:18Z","timestamp":1791000678706,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M650359"],"award-info":[{"award-number":["2019M650359"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903392"],"award-info":[{"award-number":["81903392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973109"],"award-info":[{"award-number":["81973109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC2000400"],"award-info":[{"award-number":["2018YFC2000400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Candidate genes of neuromuscular junction (NMJ) pathway increased risk of frailty, but the extent and whether can be offset by exercises was unclear. The aim of this study was to investigate the association between aerobic exercises and incident frailty regardless of NMJ pathway\u2010related genetic risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort study on participants from Chinese Longitudinal Healthy Longevity Survey was conducted from 2008 to 2011. A total of 7006 participants (mean age of 80.6\u00a0\u00b1\u00a010.3\u00a0years) without frailty at baseline were interviewed to record aerobic exercise status, and 4053 individuals among them submitted saliva samples. NMJ pathway\u2010related genes were genotyped and weighted genetic risk scores were constructed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 3.1\u00a0years (19\u00a0634 person\u2010years), there were 1345 cases (19.2%) of incident frailty. Persistent aerobic exercises were associated with a 26% lesser frailty risk [adjusted hazard ratio (\n                      <jats:italic>HR<\/jats:italic>\n                      )\u00a0=\u00a00.74, 95% confidence interval (\n                      <jats:italic>CI<\/jats:italic>\n                      )\u00a0=\u00a00.64\u20130.85]. This association was stronger in a subgroup of 1552 longevous participants (age between 90 and 111\u00a0years, adjusted\n                      <jats:italic>HR<\/jats:italic>\n                      \u00a0=\u00a00.72, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      \u00a0=\u00a00.60\u20130.87). High genetic risk was associated with a 35% increased risk of frailty (adjusted\n                      <jats:italic>HR<\/jats:italic>\n                      \u00a0=\u00a01.35, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      \u00a0=\u00a01.16\u20131.58). Of the participants with high genetic risk and no persistent aerobic exercises, there was a 59% increased risk of frailty (adjusted\n                      <jats:italic>HR<\/jats:italic>\n                      \u00a0=\u00a01.59, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      \u00a0=\u00a01.20\u20132.09).\n                      <jats:italic>HRs<\/jats:italic>\n                      for the risk of frailty increased from the low genetic risk with persistent aerobic exercise to high genetic risk without persistent aerobic exercise (\n                      <jats:italic>P<\/jats:italic>\n                      trend &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both aerobic exercises and NMJ pathway\u2010related genetic risk were significantly associated with frailty. Persistent aerobic exercises can partly offset NMJ pathway\u2010related genetic risk to frailty in elderly people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12658","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:46:14Z","timestamp":1612352774000},"page":"350-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of regular aerobic exercises and neuromuscular junction variants with incidence of frailty: an analysis of the Chinese Longitudinal Health and Longevity Survey"],"prefix":"10.1002","volume":"12","author":[{"given":"Yu\u2010Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging and Development Studies, National School of Development Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010He","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Bin","family":"Lv","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou 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