{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:41:59Z","timestamp":1781091719926,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skeletal muscle wasting and fatigue are commonly observed in cancer patients receiving chemotherapy and associated with reduced treatment outcome and quality of life. Nutritional support may mitigate these side effects, but potential interference with chemotherapy efficacy could be of concern. Here, we investigated the effects of an \u03c9\u20103 polyunsaturated fatty acid (eicosapentaenoic acid and docosahexaenoic acid), leucine\u2010enriched, high\u2010protein (100% whey), additional vitamin D, and prebiotic fibres \u2018specific nutritional composition\u2019 (SNC) and chemotherapy on state\u2010of\u2010the\u2010art tumour organoids and muscle cells and studied muscle function, physical activity, systemic inflammation, and chemotherapy efficacy in a mouse model of aggressive colorectal cancer (CRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Tumour\u2010bearing mice received a diet with or without SNC. Chemotherapy treatment consisted of oxaliplatin and 5\u2010fluorouracil. Tumour formation was monitored by calliper measurements. Physical activity was continuously monitored by infrared imaging.\n                      <jats:italic>Ex vivo<\/jats:italic>\n                      muscle performance was determined by myography, muscle fatty acid composition by gas chromatography, and plasma cytokine levels by Luminex xMAP technology. Patient\u2010derived CRC organoids and C2C12 myotubes were used to determine whether SNC affects chemotherapy sensitivity\n                      <jats:italic>in vitro<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Specific nutritional composition increased muscle contraction capacity of chemotherapy\u2010treated tumour\u2010bearing mice (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and enriched \u03c9\u20103 fatty acid composition in muscle without affecting treatment efficacy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Mice receiving SNC maintained physical activity after chemotherapy and showed decreased systemic inflammation. Therapeutic response of CRC organoids was unaffected by SNC nutrients, while cell viability and protein synthesis of muscle cells significantly improved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results show that specialized nutritional support can be used to maintain muscle function and physical activity levels during chemotherapy without increasing tumour viability. Therefore, nutritional strategies have potential value in promoting cancer and chemotherapy tolerance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12703","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T07:51:15Z","timestamp":1620373875000},"page":"796-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Specialized nutrition improves muscle function and physical activity without affecting chemotherapy efficacy in C26 tumour\u2010bearing mice"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-7377","authenticated-orcid":false,"given":"Liza A.","family":"Wijler","sequence":"first","affiliation":[{"name":"Laboratory of Translational Oncology, Division of Imaging and Cancer University Medical Centre Utrecht, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle A.E.","family":"Raats","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Oncology, Division of Imaging and Cancer University Medical Centre Utrecht, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd G.","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care University Medical Centre Utrecht, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francina J.","family":"Dijk","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanil","family":"Quirindongo","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care University Medical Centre Utrecht, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.W.","family":"Furber","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Dorresteijn","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The 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