{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:15:50Z","timestamp":1789186550332,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1174886"],"award-info":[{"award-number":["GNT1174886"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1123014"],"award-info":[{"award-number":["GNT1123014"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007465","name":"Universitetet i Troms\u00f8","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcopenia is an age\u2010related muscle disease primarily characterized by reductions in muscle strength that increases the risk of falls, fractures, cognitive impairment, and mortality. Exercise is currently preferred in prevention and treatment, but it is unknown how different habitual physical activity and sedentary behaviour patterns associate with sarcopenia status. The purpose of the present study was to compare associations of these patterns with probable sarcopenia in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 3653 community\u2010dwelling participants (51% women) aged 60\u201384\u00a0years from the seventh survey of the Troms\u00f8 Study, we assessed objective physical activity and sedentary behaviour collected over 8\u00a0days (ActiGraph wGT3X\u2010BT Accelerometer), grip strength (Jamar+ Digital Dynamometer), five\u2010repetition chair stands, and self\u2010reported disease. We combined tertiles of sedentary (SED) time and moderate\u2010to\u2010vigorous physical activity (MVPA) to create nine different activity profiles (SED<jats:sub>HIGH<\/jats:sub>, SED<jats:sub>MOD<\/jats:sub>, and SED<jats:sub>LOW<\/jats:sub> combined with MVPA<jats:sub>HIGH<\/jats:sub>, MVPA<jats:sub>MOD<\/jats:sub>, or MVPA<jats:sub>LOW<\/jats:sub>). Multiple logistic regression models were used to examine how these profiles associated with probable sarcopenia, defined by low handgrip strength and\/or slow chair stands time according to the revised European Working Group on Sarcopenia in Older People criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Probable sarcopenia was present in 227 (6.2%) participants. Men with probable sarcopenia had on average 35.3\u00a0min more SED time and 20\u00a0min less MVPA compared with participants without sarcopenia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 for all), while women with probable sarcopenia only had 18\u00a0min less MVPA (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Compared with the SED<jats:sub>HIGH<\/jats:sub>\u2013MVPA<jats:sub>LOW<\/jats:sub> reference activity profile (714.2\u00a0min SED\/day and 10.4\u00a0min MVPA\/day), the SED<jats:sub>HIGH<\/jats:sub>\u2013MVPA<jats:sub>MOD<\/jats:sub> profile (697.1\u00a0min SED\/day and 31.5\u00a0min MVPA\/day) had significantly lower odds ratio (OR) for probable sarcopenia (OR 0.17, 95% confidence interval [CI] 0.08\u20130.35), while the SED<jats:sub>LOW<\/jats:sub>\u2013MVPA<jats:sub>LOW<\/jats:sub> profile (482.9\u00a0min SED\/day and 11.0\u00a0min MVPA\/day) did not (OR 0.72, 95% CI 0.47\u20131.11). These findings were not influenced by age, sex, smoking, or self\u2010reported diseases, and higher levels of MVPA did not further decrease ORs for probable sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older adults who achieve moderate amounts of MVPA have reduced odds for probable sarcopenia, even when they have high sedentary time. Those with low sedentary time did not have reduced odds for probable sarcopenia when they also had low amounts of MVPA. These findings need confirmation in longitudinal studies but suggest that interventions for preventing sarcopenia should prioritize increasing MVPA over reducing sedentary behaviour.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12718","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T21:27:47Z","timestamp":1622582867000},"page":"955-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Moderate\u2010to\u2010vigorous physical activity modifies the relationship between sedentary time and sarcopenia: the Troms\u00f8 Study 2015\u20132016"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7912-5786","authenticated-orcid":false,"given":"Jonas","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Community Medicine UiT The Arctic University of Norway  Troms\u00f8 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of Geriatric Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila A.","family":"Hopstock","sequence":"additional","affiliation":[{"name":"Department of Community Medicine UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameline","family":"Grimsgaard","sequence":"additional","affiliation":[{"name":"Department of Community Medicine UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12411"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.09.013"},{"key":"e_1_2_8_4_1","first-page":"300","article-title":"New versus old guidelines for sarcopenia classification: what is the impact on prevalence and health 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