{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:49:18Z","timestamp":1784746158147,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Here, we aimed to propose novel lateral whole\u2010body dual\u2010energy X\u2010ray absorptiometry (lateral DXA) as a simple tool for measuring spinal muscle mass and investigate the feasibility of lateral DXA to measure lumbar paraspinal muscle (LPM) mass compared with lumbosacral spine three\u2010dimensional magnetic resonance imaging (3D MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty consecutive participants were enrolled from a prospective observational cohort (SarcoSpine study). Lateral DXA was scanned with each participant in the lateral decubitus position. The region of interest was defined to analyse the LPM mass. LPM total volume, LPM cross\u2010sectional area at the L3 mid\u2010vertebra and L4\/5 mid\u2010disc levels and each signal intensity were measured by 3D MRI. Isokinetic and isometric back extensor muscle strengths as well as back extensor endurance were examined. The correlation between lateral DXA\u2010based mass (weight) and 3D MRI\u2010based LPM volume was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the 20 participants (15 women, 5 men) was 72.2\u00a0\u00b1\u00a04.9\u00a0years. LPM mass by lateral DXA was positively correlated with LPM volume by 3D MRI (\u03b2\u00a0=\u00a00.333,<jats:italic>r<\/jats:italic>\u00a0=\u00a00.692,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and negatively correlated with signal intensity of the total LPM (\u03b2\u00a0=\u00a0\u22120.263,<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.530,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016). LPM mass was also correlated with appendicular limb muscle mass, handgrip strength and gait speed as well as back extensor endurance (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.620,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that LPM mass assessed by lateral DXA was positively correlated with LPM volume by 3D MRI in older adults. Lateral DXA may be a potential substitute for the cross\u2010sectional area measurement of LPM mass. Further studies are required to validate this lateral DXA technique.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12721","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T13:14:37Z","timestamp":1622207677000},"page":"913-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel lateral whole\u2010body dual\u2010energy X\u2010ray absorptiometry of lumbar paraspinal muscle mass: results from the SarcoSpine study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-3094","authenticated-orcid":false,"given":"Sang Yoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, SMG\u2010SNU Boramae Medical Center Seoul National University College of Medicine Seoul South 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5785-8110","authenticated-orcid":false,"given":"Sun Gun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea"},{"name":"DInstitute of Aging Seoul National University Seoul South Korea"},{"name":"Rheumatism Research Institute, Medical Research Center Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9454-0344","authenticated-orcid":false,"given":"Jae\u2010Young","family":"Lim","sequence":"additional","affiliation":[{"name":"DInstitute of Aging Seoul National University Seoul South Korea"},{"name":"Department of Rehabilitation Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam\u2010si South 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