{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:27:07Z","timestamp":1793111227936,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["82DZD00302"],"award-info":[{"award-number":["82DZD00302"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"Norges Idrettsh\u00f8gskole","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018959","name":"EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018959","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020111","name":"Therapeutic Innovation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001789","name":"Bond University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007912","name":"Department of Education and Training","doi-asserted-by":"publisher","award":["201202"],"award-info":[{"award-number":["201202"]}],"id":[{"id":"10.13039\/501100007912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP200101830"],"award-info":[{"award-number":["DP200101830"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP190103081"],"award-info":[{"award-number":["DP190103081"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1140644"],"award-info":[{"award-number":["APP1140644"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP11577321"],"award-info":[{"award-number":["APP11577321"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Knowledge of age\u2010related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a large\u2010scale epigenome\u2010wide association study meta\u2010analysis of age in human skeletal muscle from 10 studies (total\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0908 muscle methylomes from men and women aged 18\u201389\u00a0years old). We explored the genomic context of age\u2010related DNA methylation changes in chromatin states, CpG islands, and transcription factor binding sites and performed gene set enrichment analysis. We then integrated the DNA methylation data with known transcriptomic and proteomic age\u2010related changes in skeletal muscle. Finally, we updated our recently developed muscle epigenetic clock (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/MEAT.html\">https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/MEAT.html<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 6710 differentially methylated regions at a stringent false discovery rate &lt;0.005, spanning 6367 unique genes, many of which related to skeletal muscle structure and development. We found a strong increase in DNA methylation at Polycomb target genes and bivalent chromatin domains and a concomitant decrease in DNA methylation at enhancers. Most differentially methylated genes were not altered at the mRNA or protein level, but they were nonetheless strongly enriched for genes showing age\u2010related differential mRNA and protein expression. After adding a substantial number of samples from five datasets (+371), the updated version of the muscle clock (MEAT 2.0, total\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01053 samples) performed similarly to the original version of the muscle clock (median of 4.4 vs. 4.6\u00a0years in age prediction error), suggesting that the original version of the muscle clock was very accurate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We provide here the most comprehensive picture of DNA methylation ageing in human skeletal muscle and reveal widespread alterations of genes involved in skeletal muscle structure, development, and differentiation. We have made our results available as an open\u2010access, user\u2010friendly, web\u2010based tool called\n                      <jats:italic>MetaMeth<\/jats:italic>\n                      (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/sarah-voisin.shinyapps.io\/MetaMeth\/\">https:\/\/sarah\u2010voisin.shinyapps.io\/MetaMeth\/<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12741","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T06:08:13Z","timestamp":1625119693000},"page":"1064-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Meta\u2010analysis of genome\u2010wide DNA methylation and integrative omics of age in human skeletal muscle"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-7083","authenticated-orcid":false,"given":"Sarah","family":"Voisin","sequence":"first","affiliation":[{"name":"Institute for Health and Sport (iHeS) Victoria University, Footscray  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macsue","family":"Jacques","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport (iHeS) Victoria University, Footscray  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanie","family":"Landen","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport (iHeS) Victoria University, Footscray  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences &amp; Medicine Bond University  Gold Coast Qld Australia"},{"name":"Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation Queensland University of Technology (QUT)  Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa M.","family":"Haupt","sequence":"additional","affiliation":[{"name":"Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation Queensland University of Technology (QUT)  Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn R.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation Queensland University of Technology (QUT)  Kelvin Grove Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiya","family":"Gancheva","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Division of Endocrinology and Diabetology, Medical Faculty Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Ouni","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Department of Experimental Diabetology German Institute of Human Nutrition Potsdam\u2010Rehbruecke (DIfE)  Nuthetal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"J\u00e4hnert","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Department of Experimental Diabetology German Institute of Human Nutrition Potsdam\u2010Rehbruecke (DIfE)  Nuthetal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences &amp; Medicine Bond University  Gold Coast Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon G.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences &amp; Medicine Bond University  Gold Coast Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie\u2010Lee M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences &amp; Medicine Bond University  Gold Coast Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Doering","sequence":"additional","affiliation":[{"name":"School of Health, Medical and Applied Sciences Central Queensland University  Rockhampton Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gabory","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, INRAE, BREED  Jouy\u2010en\u2010Josas France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, BREED  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Junien","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, INRAE, BREED  Jouy\u2010en\u2010Josas France"},{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, BREED  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Caiazzo","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, Pasteur Institute Lille, U1190 Translational Research for Diabetes, European Genomic Institute of Diabetes  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Verkindt","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, Pasteur Institute Lille, U1190 Translational Research for Diabetes, European Genomic Institute of Diabetes  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violetta","family":"Raverdy","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, Pasteur Institute Lille, U1190 Translational Research for Diabetes, European Genomic Institute of Diabetes  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Pattou","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, Pasteur Institute Lille, U1190 Translational Research for Diabetes, European Genomic Institute of Diabetes  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Froguel","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, Pasteur Institute Lille, U1190 Translational Research for Diabetes, European Genomic Institute of Diabetes  Lille France"},{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Craig","sequence":"additional","affiliation":[{"name":"IMPACT Institute Deakin University, Geelong Waurn Ponds Campus  Geelong Vic. Australia"},{"name":"Epigenetics, Murdoch Children's Research Institute Royal Children's Hospital  Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Blocquiaux","sequence":"additional","affiliation":[{"name":"Physical Activity, Sport &amp; Health Research Group, Department of Movement Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Thomis","sequence":"additional","affiliation":[{"name":"Physical Activity, Sport &amp; Health Research Group, Department of Movement Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Sharples","sequence":"additional","affiliation":[{"name":"Institute for Physical Performance Norwegian School of Sport Sciences  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Department of Experimental Diabetology German Institute of Human Nutrition Potsdam\u2010Rehbruecke (DIfE)  Nuthetal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Division of Endocrinology and Diabetology, Medical Faculty Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Horvath","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Biostatistics, David Geffen School of Medicine University of California Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Eynon","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport (iHeS) Victoria University, Footscray  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"RoserM Ortiz\u2010OspinaE RitchieH.Life expectancy\u2014our world in data2020."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0457-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.60"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.32"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0004-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12180"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-9-r102"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12556"},{"key":"e_1_2_11_11_1","first-page":"2020.06.30.1794","article-title":"Recurrent training rejuvenates and enhances transcriptome and methylome responses in young and older human muscle","author":"Blocquiaux S","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72730-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4186-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000945"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20287-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051302"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12081-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814263116"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1066-1"},{"key":"e_1_2_11_21_1","unstructured":"SmythGK.limma: linear models for microarray data.2005https:\/\/doi.org\/10.1007\/0\u2010387\u201029362\u20100_23"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1131-9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2825"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-8-6"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3805"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt482"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx078"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14248"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.33"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09784"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv560"},{"key":"e_1_2_11_32_1","first-page":"e22","article-title":"Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes","volume":"45","author":"Zhou W","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bax028"},{"key":"e_1_2_11_34_1","first-page":"2020.08.24.2657","article-title":"Gene set enrichment analysis for genome\u2010wide DNA methylation data","author":"Maksimovic J","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-017-0189-z"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021800"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-015-0059-1"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49874"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13869-w"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11115"},{"key":"e_1_2_11_42_1","first-page":"1","article-title":"DNA methylation and body\u2010mass index: a genome\u2010wide analysis","volume":"6736","author":"Dick KJ","year":"2014","journal-title":"Lancet"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.01.022"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0159-6"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70034-8"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601033"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434120-00002"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.004"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.2.313"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00475.2001"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13048"},{"key":"e_1_2_11_52_1","first-page":"E1315","article-title":"Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function","volume":"302","author":"Watt MJ","year":"2011","journal-title":"Am J Physiol Metab"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00317.2015"},{"key":"e_1_2_11_54_1","first-page":"808642","article-title":"Erosion of the epigenetic landscape and loss of cellular identity as a cause of aging in mammals","author":"Yang J\u2010H","year":"2019","journal-title":"bioRxiv"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.08.008"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12744"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.103101.109"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-015-0118-4"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.02.007"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14042"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00608.x"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102740"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-016-0072-z"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12501"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12741","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T04:08:16Z","timestamp":1693282096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/jcsm.12741"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12741","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"2020-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}