{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:00:23Z","timestamp":1792555223754,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03 AG056444"],"award-info":[{"award-number":["R03 AG056444"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG028740"],"award-info":[{"award-number":["P30 AG028740"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM008721"],"award-info":[{"award-number":["T32 GM008721"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P50 GM111152"],"award-info":[{"award-number":["P50 GM111152"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM113945"],"award-info":[{"award-number":["R01 GM113945"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM104481"],"award-info":[{"award-number":["R01 GM104481"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM\u2010040586"],"award-info":[{"award-number":["R01 GM\u2010040586"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is a known risk factor for poor outcomes across many chronic diseases. The impact on outcomes of both pre\u2010existing sarcopenia and acute muscle wasting (AMW) in acute critical illness caused by sepsis remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective longitudinal cohort study of critically ill patients with intra\u2010abdominal sepsis utilizing abdominal computed tomography at sepsis onset to determine baseline skeletal muscle index (SMI). Biomarkers of inflammation and catabolism were measured through 28\u00a0days while hospitalized. We performed follow\u2010up evaluations of strength and physical function at 3, 6, and 12\u00a0months, with interval CT analyses at 3 and 12\u00a0months to evaluate changes in muscle mass. Measured clinical outcomes included development of chronic critical illness (\u226514\u00a0days in intensive care with persistent organ dysfunction), long\u2010term functional status, and 1\u00a0year mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 47 sepsis patients enrolled (mean age 53\u00a0\u00b1\u00a014\u00a0years), half (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a023; 49%) were sarcopenic at baseline. Overall, sepsis patients exhibited acute and persistent muscle wasting with an average 8% decrease in SMI from baseline at 3\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0008). Sarcopenic (SAR) and non\u2010sarcopenic (NSAR) groups were similar in regards to age and comorbidity burden. SAR patients had greater acute physiologic derangement (APACHE II, 18 vs. 12.5), higher incidence of multiple organ failure (57% vs. 17%), longer hospital (21 vs. 12\u00a0days) and intensive care unit length of stays (13 vs. 4\u00a0days), and higher inpatient mortality (17% vs. 0%; all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Pre\u2010existing SAR was a strong independent predictor of early death or developing chronic critical illness (odds ratio 11.87, 95% confidence interval CI 1.88\u201374.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.009, area under the curve 0.880) and was associated with significantly higher risk of 1\u2010year mortality (34.9% vs. 4.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007). Lower baseline SMI was also predictive of poor functional status at 12\u00a0months (OR 0.89, 95% confidence interval 0.80\u20130.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.039, area under the curve 0.867). Additionally, SAR patients had AMW with persistent muscle mass loss at 3\u00a0months that was associated with decreased health\u2010related quality of life and SF\u201036 physical function domains (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Persistent AMW at 3\u00a0months was not predictive of mortality or poor functional status, with return to near\u2010baseline muscle mass among sepsis survivors by 6\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Critically ill patients have an acute and persistent loss of muscle mass after intra\u2010abdominal sepsis, which is associated with decreased health\u2010related quality of life and physical function at 3\u00a0months. However, pre\u2010existing sarcopenia, rather than persistent acute muscle mass loss at 3\u00a0months after sepsis, is independently associated with poor long\u2010term functional status and increased 1\u00a0year mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12752","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T06:30:37Z","timestamp":1625121037000},"page":"1203-1213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["The impact of sarcopenia and acute muscle mass loss on long\u2010term outcomes in critically ill patients with intra\u2010abdominal sepsis"],"prefix":"10.1002","volume":"12","author":[{"given":"Michael C.","family":"Cox","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Ghita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongkai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gardner","sequence":"additional","affiliation":[{"name":"Institute on Aging University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell B.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dijoia B.","family":"Darden","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan","family":"Leeuwenburgh","sequence":"additional","affiliation":[{"name":"Institute on Aging University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle L.","family":"Moldawer","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Efron","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Anton","sequence":"additional","affiliation":[{"name":"Institute on Aging University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-3718","authenticated-orcid":false,"given":"Scott C.","family":"Brakenridge","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00260"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328340c2c2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy212"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0315"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.14635"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114550189"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.04.027"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12221"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13691"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-016-0205-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.05.024"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278481"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201512-2344OC"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015136"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000121"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12501"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003655"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318265f340"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31817d69a6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1525"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4429-z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001758"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.10.049"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90093-7"},{"key":"e_1_2_8_30_1","article-title":"Association of interleukin\u20108 with cachexia from patients with low\u2010third gastric cancer","author":"Song B","year":"2009","journal-title":"Comp Funct Genomics"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532051"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003458"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2257OC"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0772-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b6e439"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2016.12.001"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.231"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.08.002"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12752","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12752","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T03:31:09Z","timestamp":1764041469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/jcsm.12752"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12752","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"2020-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}