{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:32:32Z","timestamp":1793748752725,"version":"4.6.1"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["03Z22CN11"],"award-info":[{"award-number":["03Z22CN11"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81X3400107"],"award-info":[{"award-number":["81X3400107"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81Z5400153"],"award-info":[{"award-number":["81Z5400153"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["231396381\/GRK1947"],"award-info":[{"award-number":["231396381\/GRK1947"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FI 965\/9\u20101"],"award-info":[{"award-number":["FI 965\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FI 965\/5\u20102"],"award-info":[{"award-number":["FI 965\/5\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FI 965\/5\u20101"],"award-info":[{"award-number":["FI 965\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin\u20101\u03b2 (IL\u20101\u03b2), activated by the NLRP3 inflammasome, compromises cardiac function. Whether or not deleting\n                      <jats:italic>Nlrp3<\/jats:italic>\n                      would prevent cardiac atrophy and improve diastolic cardiac function in sepsis was unclear. Here, we investigated the role of NLRP3\/IL\u20101\u03b2 in sepsis\u2010induced cardiomyopathy and cardiac atrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Male<\/jats:bold>\n                      <jats:italic>Nlrp3<\/jats:italic>\n                      knockout (KO) and wild\u2010type (WT) mice were exposed to polymicrobial sepsis by caecal ligation and puncture (CLP) surgery (KO,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a027; WT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a033) to induce septic cardiomyopathy. Sham\u2010treated mice served as controls (KO,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011; WT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016). Heart weights and morphology, echocardiography and analyses of gene and protein expression were used to evaluate septic cardiomyopathy and cardiac atrophy. IL\u20101\u03b2 effects on primary and immortalized cardiomyocytes were investigated by morphological and molecular analyses. IonOptix and real\u2010time deformability cytometry (RT\u2010DC) analysis were used to investigate functional and mechanical effects of IL\u20101\u03b2 on cardiomyocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Heart morphology and echocardiography revealed preserved systolic (stroke volume: WT sham vs. WT CLP: 33.1\u00a0\u00b1\u00a07.2\u00a0\u03bcL vs. 24.6\u00a0\u00b1\u00a08.7\u00a0\u03bcL,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05; KO sham vs. KO CLP: 28.3\u00a0\u00b1\u00a08.1\u00a0\u03bcL vs. 29.9\u00a0\u00b1\u00a09.9\u00a0\u03bcL, n.s.;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 vs. WT CLP) and diastolic (peak E wave velocity: WT sham vs. WT CLP: 750\u00a0\u00b1\u00a0132 vs. 522\u00a0\u00b1\u00a0200\u00a0mm\/s,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; KO sham vs. KO CLP: 709\u00a0\u00b1\u00a0152 vs. 639\u00a0\u00b1\u00a0165\u00a0mm\/s, n.s.;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 vs. WT CLP) cardiac function and attenuated cardiac (heart weight\u2013tibia length ratio: WT CLP vs. WT sham: \u221226.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05; KO CLP vs. KO sham: \u22123.3%, n.s.;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 vs. WT CLP) and cardiomyocyte atrophy in KO mice during sepsis. IonOptix measurements showed that IL\u20101\u03b2 decreased contractility (cell shortening: IL\u20101\u03b2: \u221215.4\u00a0\u00b1\u00a02.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 vs. vehicle, IL\u20101RA: \u22126.1\u00a0\u00b1\u00a03.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 vs. IL\u20101\u03b2) and relaxation of adult rat ventricular cardiomyocytes (time\u2010to\u201050% relengthening: IL\u20101\u03b2: 2071\u00a0\u00b1\u00a0225\u00a0ms,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 vs. vehicle, IL\u20101RA: 564\u00a0\u00b1\u00a0247\u00a0ms,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 vs. IL\u20101\u03b2), which was attenuated by an IL\u20101 receptor antagonist (IL\u20101RA). RT\u2010DC analysis indicated that IL\u20101\u03b2 reduced cardiomyocyte size (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and deformation (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). RNA sequencing showed that genes involved in NF\u2010\u03baB signalling, autophagy and lysosomal protein degradation were enriched in hearts of septic WT but not in septic KO mice. Western blotting and qPCR disclosed that IL\u20101\u03b2 activated NF\u2010\u03baB and its target genes, caused atrophy and decreased myosin protein in myocytes, which was accompanied by an increased autophagy gene expression. These effects were attenuated by IL\u20101RA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL\u20101\u03b2 causes atrophy, impairs contractility and relaxation and decreases deformation of cardiomyocytes. Because NLRP3\/IL\u20101\u03b2 pathway inhibition attenuates cardiac atrophy and cardiomyopathy in sepsis, it could be useful to prevent septic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12763","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T07:42:22Z","timestamp":1630568542000},"page":"1653-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Inhibition of the NLRP3\/IL\u20101\u03b2 axis protects against sepsis\u2010induced cardiomyopathy"],"prefix":"10.1002","volume":"12","author":[{"given":"Katharina","family":"Busch","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Max Delbr\u00fcck Center (MDC) for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Kny","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Max Delbr\u00fcck Center (MDC) for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Huang","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Max Delbr\u00fcck Center (MDC) for Molecular Medicine in the Helmholtz Association  Berlin Germany"},{"name":"Department of Cardiology Heart Center Brandenburg and Medical School Brandenburg (MHB)  Bernau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman E.","family":"Klassert","sequence":"additional","affiliation":[{"name":"ZIK Septomics, Host Septomics  Jena Germany"},{"name":"Jena University Hospital, Integrated Research and Treatment Center \u2010 Center for Sepsis Control and Care (CSCC)  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Stock","sequence":"additional","affiliation":[{"name":"ZIK Septomics, Host Septomics  Jena Germany"},{"name":"Jena University Hospital, Integrated Research and Treatment Center \u2010 Center for Sepsis Control and Care (CSCC)  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hahn","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Max Delbr\u00fcck Center (MDC) for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Graeger","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail","family":"Todiras","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Peptide Hormones Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"},{"name":"Nicolae Testemi\u0163anu State University of Medicine and Pharmacy  Chi\u0219in\u0103u Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Max Delbr\u00fcck Center (MDC) for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishwas","family":"Chamling","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Greifswald  Greifswald Germany"},{"name":"Department of Internal Medicine B, Molecular Cardiology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Willenbrock","sequence":"additional","affiliation":[{"name":"Signal Transduction in Development and Cancer Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Greifswald  Greifswald Germany"},{"name":"Department of Internal Medicine B, Molecular Cardiology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Biedenweg","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Greifswald  Greifswald Germany"},{"name":"Centre for Innovation Competence \u2010 Humoral Immune Response in Cardiovascular Diseases University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Heuser","sequence":"additional","affiliation":[{"name":"Animal Phenotyping Facility Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Scheidereit","sequence":"additional","affiliation":[{"name":"Signal Transduction in Development and Cancer Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Brandenburg and Medical School Brandenburg (MHB)  Bernau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan B.","family":"Felix","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Greifswald  Greifswald Germany"},{"name":"Department of Internal Medicine B, Molecular Cardiology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Otto","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Greifswald  Greifswald Germany"},{"name":"Centre for Innovation Competence \u2010 Humoral Immune Response in Cardiovascular Diseases University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich C.","family":"Luft","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Max Delbr\u00fcck Center (MDC) for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortense","family":"Slevogt","sequence":"additional","affiliation":[{"name":"ZIK Septomics, Host Septomics  Jena Germany"},{"name":"Jena University Hospital, Integrated Research and Treatment Center \u2010 Center for Sepsis Control and Care (CSCC)  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8522-1045","authenticated-orcid":false,"given":"Jens","family":"Fielitz","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Max Delbr\u00fcck Center (MDC) for Molecular Medicine in the Helmholtz Association  Berlin Germany"},{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Greifswald  Greifswald Germany"},{"name":"Department of Internal Medicine B, Molecular Cardiology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3367-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000114827.93410.D8"},{"key":"e_1_2_11_4_1","first-page":"660","article-title":"Myocardial depression characterizes the fatal course of septic shock","volume":"111","author":"Vincent JL","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr351"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.08.1037"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-4-483"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012260"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510470040032"},{"key":"e_1_2_11_10_1","first-page":"460","article-title":"Interleukin\u20101\u2010induced myocardial depression in an isolated beating heart preparation","volume":"8","author":"Hosenpud JD","year":"1989","journal-title":"J Heart Transplant"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(93)90075-A"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.949"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068809"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101215"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600728R"},{"key":"e_1_2_11_17_1","first-page":"417","article-title":"Role of TXNIP\/NLRP3 in sepsis\u2010induced myocardial dysfunction","volume":"44","author":"Yang C","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6125"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.04.014"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108586108"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200902200208"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000247"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034621"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316710"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001059"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-268730"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-273656"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.01.002"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01972-5"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12410"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0706-2"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-016-0115-0"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12491"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12057"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.04.025"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3281"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7346-0_15"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3224-9"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.02.017"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00975"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107639"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000266683.64081.02"},{"key":"e_1_2_11_44_1","first-page":"147","article-title":"Cytokine appearance in human endotoxemia and primate bacteremia","volume":"166","author":"Hesse DG","year":"1988","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.018"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316710"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318214b67e"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01051.2008"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.07.084"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.13-388"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12501"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:59:33Z","timestamp":1693184373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/jcsm.12763"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12763","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"2020-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}