{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:22:20Z","timestamp":1792221740435,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309200"],"award-info":[{"award-number":["2017YFC1309200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>Hand grip strength (HGS) is one of diagnose criteria factors of sarcopenia and is associated with the survival of patients with cancer. However, few studies have addressed the association of HGS and 1\u00a0year mortality of patients with cancer cachexia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study included 8466 patients with malignant solid tumour from 40 clinical centres throughout China. Cachexia was diagnosed using the 2011 International cancer cachexia consensus. The hazard ratio (HR) of all cancer cachexia mortality was calculated using Cox proportional hazard regression models. Kaplan\u2013Meier curves were generated to evaluate the association between HGS and the 1\u00a0year mortality of patients with cancer cachexia. The interaction analysis was used to explore the combined effect of low HGS and other factors on the overall survival of patients with cancer cachexia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among all participants, 1434 (16.9%) patients with cancer were diagnosed with cachexia according to the 2011 International cancer cachexia consensus with a mean (SD) age of 57.75 (12.97) years, among which there were 871 (60.7%) male patients. The HGS optimal cut\u2010off points of male and female patients were 19.87 and 14.3\u00a0kg, respectively. Patients with cancer cachexia had lower HGS than those patients without cachexia (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). In the multivariable Cox analysis, low HGS was an independent risk factor of cachexia [HR: 1.491, 95% confidence interval (CI): 1.257\u20131.769] after adjusting other factors. In addition, all of cancer cachexia patients with lower HGS had unfavourable 1\u00a0year survival (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In a subset analysis, low HGS was an independent prognosis factor of male patients with cancer cachexia (HR: 1.623, 95% CI: 1.308\u20132.014,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), but not in female patients (HR: 1.947, 95% CI: 0.956\u20133.963,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0662), and low HGS was associated with poor 1\u00a0year survival of digestive system, respiratory system, and other cancer cachexia patients (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Low HGS has combined effects with high neutrophil\u2010to\u2010lymphocyte ratio or low albumin on unfavourable overall survival of patients with cancer cachexia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low HGS was associated with poor 1\u00a0year survival of patients with cancer cachexia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12778","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T01:40:09Z","timestamp":1632188409000},"page":"1489-1500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Associations of low hand grip strength with 1\u00a0year mortality of cancer cachexia: a multicentre observational study"],"prefix":"10.1002","volume":"12","author":[{"given":"Mengmeng","family":"Song","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotian","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"},{"name":"Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing China"},{"name":"School of Clinical Medicine Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center First Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, Henan Key Laboratory of Tumor Epidemiology College of Public Health Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-8693","authenticated-orcid":false,"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery\/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital  Beijing China"},{"name":"Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition  Beijing 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