{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:26:51Z","timestamp":1771104411477,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["WELBIO\u2010CR\u20102019C\u201002R"],"award-info":[{"award-number":["WELBIO\u2010CR\u20102019C\u201002R"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_163144"],"award-info":[{"award-number":["320030_163144"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Protein energy wasting is associated with negative outcome in patients under chronic haemodialysis (HD). Branched\u2010chain amino acids (BCAAs) may increase the muscle mass. This post hoc<\/jats:italic> analysis of a controlled double\u2010blind randomized crossover study assessed the impact of BCAAs on nutritional status, physical function, and quality of life.<\/jats:p><\/jats:sec>Methods<\/jats:title>We included 36 chronic HD patient features of protein energy wasting as plasma albumin <38\u00a0g\/L, and dietary intakes <30\u00a0kcal\/kg\/day and <1\u00a0g protein\/kg\/day. Patients received either oral BCAA (2\u00a0\u00d7\u00a07\u00a0g\/day) or glycine (2\u00a0\u00d7\u00a07\u00a0g\/day) for 4\u00a0months (Period 1), followed by a washout period of 1\u00a0month, and then received the opposite supplement (Period 2). The outcomes were lean body mass measured by dual\u2010energy X\u2010ray absorptiometry, fat\u2010free mass index measured by bioelectrical impedance, resting energy expenditure, dietary intake and appetite rating, physical activity and function, quality of life, and blood parameters. Analyses were performed by multiple mixed linear regressions including type of supplementation, months, period, sex, and age as fixed effects and subjects as random intercepts.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010seven patients (61.2\u00a0\u00b1\u00a013.7\u00a0years, 41% women) were compliant to the supplementations (consumption >80% of packs) and completed the study. BCAA did not affect lean body mass index and body weight, but significantly decreased fat\u2010free mass index, as compared with glycine (coeff \u22120.27, 95% confidence interval \u22120.43 to \u22120.10, P<\/jats:italic>\u00a0=\u00a00.002, respectively). BCAA and glycine intake had no effect on the other clinical parameters, blood chemistry tests, or plasma amino acids.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Branched\u2010chain amino acid did not improve lean body mass as compared with glycine. Unexpectedly, glycine improved fat\u2010free mass index in HD patients, as compared with BCAA. Whether long\u2010term supplementation with glycine improves the clinical outcome remains to be demonstrated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12780","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T12:29:48Z","timestamp":1631622588000},"page":"1540-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Glycine increases fat\u2010free mass in malnourished haemodialysis patients: a randomized double\u2010blind crossover trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-5203","authenticated-orcid":false,"given":"Laurence","family":"Genton","sequence":"first","affiliation":[{"name":"Unit of Clinical Nutrition Geneva University Hospitals and University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Teta","sequence":"additional","affiliation":[{"name":"Service 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