{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:55:13Z","timestamp":1792677313918,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["72190067"],"award-info":[{"award-number":["72190067"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is defined as the loss of muscle mass and strength. Despite the seriousness of this disease, a single diagnostic criterion has not yet been established. Few studies have reported the prevalence of sarcopenia globally, and there is a high level of heterogeneity between studies, stemmed from the diagnostic criteria of sarcopenia and the target population. The aims of this systematic review and meta\u2010analysis were (i) to identify and summarize the diagnostic criteria used to define sarcopenia and severe sarcopenia and (ii) to estimate the global and region\u2010specific prevalence of sarcopenia and severe sarcopenia by sociodemographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Embase, MEDLINE, and Web of Science Core Collections were searched using relevant MeSH terms. The inclusion criteria were cross\u2010sectional or cohort studies in individuals aged \u226518\u00a0years, published in English, and with muscle mass measured using dual\u2010energy x\u2010ray absorptiometry, bioelectrical impedance, or computed tomography (CT) scan. For the meta\u2010analysis, studies were stratified by diagnostic criteria (classifications), cut\u2010off points, and instruments to assess muscle mass. If at least three studies reported the same classification, cut\u2010off points, and instrument to measure muscle mass, they were considered suitable for meta\u2010analysis. Following this approach, 6 classifications and 23 subgroups were created. Overall pooled estimates with inverse\u2010variance weights obtained from a random\u2010effects model were estimated using the\n                      <jats:italic>metaprop<\/jats:italic>\n                      command in Stata.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 19\u00a0320 studies, 263 were eligible for the narrative synthesis and 151 for meta\u2010analysis (total\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0692\u00a0056, mean age: 68.5\u00a0years). Using different classifications and cut\u2010off points, the prevalence of sarcopenia varied between 10% and 27% in the studies included for meta\u2010analysis. The highest and lowest prevalence were observed in Oceania and Europe using the European Working Group on Sarcopenia in Older People (EWGSOP) and EWGSOP2, respectively. The prevalence ranged from 8% to 36% in individuals &lt;60\u00a0years and from 10% to 27% in \u226560\u00a0years. Men had a higher prevalence of sarcopenia using the EWGSOP2 (11% vs. 2%) while it was higher in women using the International Working Group on Sarcopenia (17% vs. 12%). Finally, the prevalence of severe sarcopenia ranged from 2% to 9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of sarcopenia and severe sarcopenia varied considerably according to the classification and cut\u2010off point used. Considering the lack of a single diagnostic for sarcopenia, future studies should adhere to current guidelines, which would facilitate the comparison of results between studies and populations across the globe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12783","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T02:43:18Z","timestamp":1637721798000},"page":"86-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1422,"title":["Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-4962","authenticated-orcid":false,"given":"Fanny","family":"Petermann\u2010Rocha","sequence":"first","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow  Glasgow UK"},{"name":"British Heart Foundation Glasgow Cardiovascular Research 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