{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:01:48Z","timestamp":1793826108351,"version":"4.6.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301571\/2017\u20101"],"award-info":[{"award-number":["301571\/2017\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301914\/2017\u20106"],"award-info":[{"award-number":["301914\/2017\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["428242\/2018\u20109"],"award-info":[{"award-number":["428242\/2018\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["166622\/2020\u20106"],"award-info":[{"award-number":["166622\/2020\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Strength and muscle mass are predictors of relevant clinical outcomes in critically ill patients, but in hospitalized patients with COVID\u201019, it remains to be determined. In this prospective observational study, we investigated whether muscle strength or muscle mass are predictive of hospital length of stay (LOS) in patients with moderate to severe COVID\u201019 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated prospectively 196 patients at hospital admission for muscle mass and strength. Ten patients did not test positive for SARS\u2010CoV\u20102 during hospitalization and were excluded from the analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sample comprised patients of both sexes (50% male) with a mean age (SD) of 59 (\u00b115) years, body mass index of 29.5 (\u00b16.9) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . The prevalence of current smoking patients was 24.7%, and more prevalent coexisting conditions were hypertension (67.7%), obesity (40.9%), and type 2 diabetes (36.0%). Mean (SD) LOS was 8.6\u00a0days (7.7); 17.0% of the patients required intensive care; 3.8% used invasive mechanical ventilation; and 6.6% died during the hospitalization period. The crude hazard ratio (HR) for LOS was greatest for handgrip strength comparing the strongest versus other patients (1.47 [95% CI: 1.07\u20132.03;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.019]). Evidence of an association between increased handgrip strength and shorter hospital stay was also identified when handgrip strength was standardized according to the sex\u2010specific mean and standard deviation (1.23 [95% CI: 1.06\u20131.43;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007]). Mean LOS was shorter for the strongest patients (7.5\u00a0\u00b1\u00a06.1\u00a0days) versus others (9.2\u00a0\u00b1\u00a08.4\u00a0days). Evidence of associations were also present for vastus lateralis cross\u2010sectional area. The crude HR identified shorter hospital stay for patients with greater sex\u2010specific standardized values (1.20 [95% CI: 1.03\u20131.39;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.016]). Evidence was also obtained associating longer hospital stays for patients with the lowest values for vastus lateralis cross\u2010sectional area (0.63 [95% CI: 0.46\u20130.88;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006). Mean LOS for the patients with the lowest muscle cross\u2010sectional area was longer (10.8\u00a0\u00b1\u00a08.8\u00a0days) versus others (7.7\u00a0\u00b1\u00a07.2\u00a0days). The magnitude of associations for handgrip strength and vastus lateralis cross\u2010sectional area remained consistent and statistically significant after adjusting for other covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Muscle strength and mass assessed upon hospital admission are predictors of LOS in patients with moderate to severe COVID\u201019, which stresses the value of muscle health in prognosis of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12789","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T02:44:40Z","timestamp":1631673880000},"page":"1871-1878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Muscle strength and muscle mass as predictors of hospital length of stay in patients with moderate to severe COVID\u201019: a prospective observational study"],"prefix":"10.1002","volume":"12","author":[{"given":"Saulo","family":"Gil","sequence":"first","affiliation":[{"name":"Applied Physiology &amp; Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP Universidade de Sao Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM\u201066), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Jacob Filho","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM\u201066), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Katsuyuki","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ferriolli","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM\u201066), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"},{"name":"Division of Internal and Geriatric Medicine, Department of Internal Medicine \u2013 Ribeir\u00e3o Preto Medical School Universidade de Sao Paulo  Ribeirao Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Leopold","family":"Busse","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM\u201066), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Junqueira","family":"Avelino\u2010Silva","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica em Envelhecimento (LIM\u201066), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Longobardi","sequence":"additional","affiliation":[{"name":"Applied Physiology &amp; 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