{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:00:57Z","timestamp":1790805657522,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010CA138624"],"award-info":[{"award-number":["R01\u2010CA138624"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Poor cardiorespiratory fitness (CRF) is a cardinal feature of post\u2010treatment primary lung cancer. The most effective exercise therapy regimen to improve CRF has not been determined.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this parallel\u2010group factorial randomized controlled trial, lung cancer survivors with poor CRF (below age\u2013sex sedentary values) were randomly allocated to receive 48 consecutive supervised sessions thrice weekly of (i) aerobic training (AT)\u2014cycle ergometry at 55% to >95% of peak oxygen consumption (VO\n 2<\/jats:sub>\n peak); (ii) resistance training (RT)\u2014lower and upper extremity exercises at 50\u201385% of maximal strength; (iii) combination training (CT)\u2014AT plus RT; or (iv) stretching attention control (AC) for 16\u00a0weeks. The primary endpoint was change in CRF (VO\n 2<\/jats:sub>\n peak, mL\u00a0O\n 2<\/jats:sub>\n \u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n ). Secondary endpoints were body composition, muscle strength, patient\u2010reported outcomes, tolerability (relative dose intensity of exercise), and safety. Analysis of covariance determined change in primary and secondary endpoints from baseline to post\u2010intervention (Week 17) with adjustment for baseline values of the endpoint and other relevant clinical covariates.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ninety patients (65\u00a0\u00b1\u00a09\u00a0years; 66% female) were randomized (AT,\n n<\/jats:italic>\n \u00a0=\u00a024; RT,\n n<\/jats:italic>\n \u00a0=\u00a023; CT,\n n<\/jats:italic>\n \u00a0=\u00a020; and AC,\n n<\/jats:italic>\n \u00a0=\u00a023) of the planned\n n<\/jats:italic>\n \u00a0=\u00a0160. No serious adverse events were observed. For the overall cohort, the lost\u2010to\u2010follow\u2010up rate was 10%. Mean attendance was \u226575% in all groups. In intention\u2010to\u2010treat analysis, VO\n 2<\/jats:sub>\n peak increased 1.1\u00a0mL\u00a0O\n 2<\/jats:sub>\n \u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n [95% confidence interval (CI): 0.0, 2.2,\n P<\/jats:italic>\n \u00a0=\u00a00.04] and 1.4\u00a0mL\u00a0O\n 2<\/jats:sub>\n \u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n (95% CI: 0.2, 2.5,\n P<\/jats:italic>\n \u00a0=\u00a00.02) in AT and CT, respectively, compared with AC. There was no difference in VO\n 2<\/jats:sub>\n peak change between RT and AC (\u22120.1\u00a0mL\u00a0O\n 2<\/jats:sub>\n \u00b7kg\n \u22121<\/jats:sup>\n \u00b7min\n \u22121<\/jats:sup>\n , 95% CI: \u22121.2, 1.0,\n P<\/jats:italic>\n \u00a0=\u00a00.88). Favourable improvements in maximal strength and body composition were observed in RT and CT groups compared with AT and AC groups (\n P<\/jats:italic>\n s\u00a0<\u00a00.05). No between\u2010group changes were observed for any patient\u2010reported outcomes. Relative dose intensity of exercise was lower in RT and CT compared with AT (\n P<\/jats:italic>\n s\u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In the context of a smaller than planned sample size, AT and CT significantly improved VO\n 2<\/jats:sub>\n peak in lung cancer survivors; however, the tolerability\u2010to\u2010benefit ratio was superior for AT and hence may be the preferred modality to target impaired CRF in post\u2010treatment lung cancer survivors.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcsm.12828","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T01:36:24Z","timestamp":1634780184000},"page":"1456-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Effects and tolerability of exercise therapy modality on cardiorespiratory fitness in lung cancer: a randomized controlled trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-5800","authenticated-orcid":false,"given":"Jessica M.","family":"Scott","sequence":"first","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"James E.","family":"Herndon","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony F.","family":"Yu","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Rusch","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Huang","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Capaci","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna N.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis J.","family":"Stoeckel","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Norwegian School of Sport Sciences Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Edvardsen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Norwegian School of Sport Sciences Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan G.","family":"Michalski","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil D.","family":"Eves","sequence":"additional","affiliation":[{"name":"University of British Columbia Kelowna BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"},{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.6.1511"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.45.7.497"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25396"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.04.029"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0463"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(89)80032-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008313430907"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt375"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1452-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.09.125"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23967"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22830"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1305"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.supplement_2.mfa-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-155"},{"key":"e_1_2_10_18_1","first-page":"359","article-title":"Assessment of leisure time exercise behavior by self\u2010report: a concurrent validity study","volume":"77","author":"Godin G","year":"1986","journal-title":"Can J Public Health"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.1.160"},{"key":"e_1_2_10_20_1","first-page":"226","volume-title":"ACSM's Guidelines for Graded Exercise Testing and Prescription","author":"American College of Sports Medicine","year":"2018"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12042"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31368"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001545"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181e52e69"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-5002(95)00450-F"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.570"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025014509626"},{"key":"e_1_2_10_29_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland CS","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.07.024"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205944"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-2292"},{"key":"e_1_2_10_34_1","first-page":"CD003793","article-title":"Pulmonary rehabilitation for chronic obstructive pulmonary disease","volume":"2","author":"McCarthy B","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.5809"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000370"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9807034"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.06.001"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-112339"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.024671"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043483"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.11.010"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735415572887"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.01.011"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12055"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002127"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw7610"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.024"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12501"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:59:39Z","timestamp":1693184379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,17]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/jcsm.12828"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12828","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,17]]},"assertion":[{"value":"2021-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}