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Diabetes mellitus patients have a higher prevalence of sarcopenia, which greatly aggravates the metabolic disturbance and compromises treatment response. Preclinical and clinical studies have shown differential impacts of anti\u2010diabetic drugs on skeletal muscle mass, strength, and performance, highlighting the importance of rational therapeutic regimen from the perspective of sarcopenia risk. In this review, we provide an update on the regulation of muscle mass and quality by major anti\u2010diabetic drugs, focusing primarily on emerging data from clinical studies. We also discuss the underlying mechanisms and clinical implications for optimal selection of anti\u2010diabetic drugs to reduce the risk of sarcopenia. In view of the lifelong use of anti\u2010diabetic drugs, we propose that a better understanding of the sarcopenia risk and interventional strategies is worthy of attention in future studies.<\/jats:p>","DOI":"10.1002\/jcsm.12838","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:02:36Z","timestamp":1634857356000},"page":"1368-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Anti\u2010diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7420-8125","authenticated-orcid":false,"given":"Xueli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu 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