{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:53:22Z","timestamp":1784202802320,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Body weight scales to height with a power of \u22482 (weight\/height<jats:sup>2<\/jats:sup>), forming the basis of body mass index (BMI). The corresponding scaling of body composition measured by abdominal computed tomography (CT) to height has not been established. The objective of this analysis was to quantify the scaling of body composition measured by a single\u2010slice axial abdominal CT image (skeletal muscle, and visceral, subcutaneous, and total adipose tissue) to height in patients with colorectal cancer (CRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included non\u2010Hispanic white males and females, aged 18\u201380\u00a0years, who were diagnosed with stage I\u2013III CRC at an integrated health care system in North America between January 2006 and December 2011. Body composition was measured by a single\u2010slice axial CT image of the third lumbar vertebra and analysed with a semi\u2010automated threshold segmentation procedure. Allometric regression models were used to quantify height scaling powers (<jats:italic>\u03b2<\/jats:italic>\u00a0\u00b1\u00a0standard error) for each body composition measure, adjusted for age, for males and females. An interaction test was used to determine if height scaling powers were statistically significantly different between males and females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2036 subjects, the mean (standard deviation) age was 64\u00a0\u00b1\u00a011\u00a0years, 1008 (49.5%) were female, and the mean (standard deviation) BMI was 27.9\u00a0\u00b1\u00a05.4\u00a0kg\/m<jats:sup>2<\/jats:sup>. Powers for skeletal muscle area were 1.06\u00a0\u00b1\u00a00.12 for males and 0.80\u00a0\u00b1\u00a00.12 for females (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049). Powers for visceral adipose tissue area were 1.81\u00a0\u00b1\u00a00.64 for males and 0.57\u00a0\u00b1\u00a00.79 for females (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.16). Powers for subcutaneous adipose tissue area were 2.04\u00a0\u00b1\u00a00.42 for males and 0.81\u00a0\u00b1\u00a00.45 for females (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.056). Powers for total abdominal adipose tissue area were 1.80\u00a0\u00b1\u00a00.46 for males and 0.76\u00a0\u00b1\u00a00.50 for females (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Body composition measured by single\u2010slice axial abdominal CT, particularly muscle area, scales to height with age\u2010adjusted powers that are different than 2 and are distinct between males and females. These observations may have implications for the development of height\u2010adjusted body composition indices in patients with cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12847","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T07:42:43Z","timestamp":1636184563000},"page":"203-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Scaling of computed tomography body composition to height: relevance of height\u2010normalized indices in patients with colorectal cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-4913","authenticated-orcid":false,"given":"Justin C.","family":"Brown","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge LA USA"},{"name":"LSU Health Sciences Center New Orleans School of Medicine  New Orleans LA USA"},{"name":"Stanley S. Scott Cancer Center Louisiana State University Health Sciences Center  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven B.","family":"Heymsfield","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bette J.","family":"Caan","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California  Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.12.2519"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.088831"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(72)90027-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437739.71477.ee"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0439"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000395"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-016-0539-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-082117-051723"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.071399"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0200"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.17.1.527"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.1.82"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.2.271"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.111203"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.3065"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12379"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.030"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.149"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79471-z"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12358"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.6.1392"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113451"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0695"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2003.12.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.007161"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.23252"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.201"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12947"},{"key":"e_1_2_8_32_1","first-page":"42","article-title":"Some 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