{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:28Z","timestamp":1791821128728,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006393","name":"Universidad de Granada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006393","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 466\u00a0788 participants of the UK Biobank (median age 56.5\u00a0years, 54.5% women). The outcome was all\u2010cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Excluding the first 2\u00a0years of follow\u2010up (landmark analysis), mean follow\u2010up was 9.1\u00a0years (inter\u2010quartile range: 8.3; 9.7) for incidence and 9.3 (inter\u2010quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower grip strength was associated with a higher risk of all\u2010cause dementia incidence and mortality, independently of important confounding factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12857","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T07:40:14Z","timestamp":1650526814000},"page":"1514-1525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Handgrip strength and all\u2010cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-1770","authenticated-orcid":false,"given":"Irene","family":"Esteban\u2010Cornejo","sequence":"first","affiliation":[{"name":"PROFITH \u201cPROmoting FITness and Health through physical activity\u201d Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences University of Granada  Granada Spain"},{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick K.","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Petermann\u2010Rocha","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow  Glasgow UK"},{"name":"Faculty of Medicine Universidad Diego Portales  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lyall","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Martinez\u2010Gomez","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Autonomous University of Madrid\/IdiPaz, CIBER of Epidemiology and Public Health (CIBERESP)  Madrid Spain"},{"name":"IMDEA Food Institute, CEI UAM\u00a0+\u00a0CSIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-3535","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Cabanas\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"IMDEA Food Institute, CEI UAM\u00a0+\u00a0CSIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco B.","family":"Ortega","sequence":"additional","affiliation":[{"name":"PROFITH \u201cPROmoting FITness and Health through physical activity\u201d Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences University of Granada  Granada Spain"},{"name":"Faculty of Sport and Health Sciences University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Hillman","sequence":"additional","affiliation":[{"name":"Department of Psychology Northeastern University  Boston MA USA"},{"name":"Department of Physical Therapy, Movement &amp; 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