{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:23:35Z","timestamp":1790774615106,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["WSN\u2010175"],"award-info":[{"award-number":["WSN\u2010175"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970218"],"award-info":[{"award-number":["81970218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770440"],"award-info":[{"award-number":["81770440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800311"],"award-info":[{"award-number":["81800311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970217"],"award-info":[{"award-number":["81970217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2008505"],"award-info":[{"award-number":["2020YFC2008505"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Unintentional weight loss (cachexia) has been associated with poor outcomes in chronic heart failure (CHF). Meteorin\u2010like (Metrnl) is a novel myokine with protective effects on cardiovascular diseases. However, the change of Metrnl concentrations and its role in elderly patients with CHF remains unclear. The aim of this study was to evaluate the association of serum Metrnl with weight loss and outcomes in elderly patients with CHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 931 consecutive elderly patients (aged 60\u00a0years and older) with CHF and 135 age\u2010matched and sex\u2010matched control subjects were enrolled. Serum Metrnl concentration was measured by enzyme\u2010linked immunosorbent assay. Body weight was measured at baseline and 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median of serum Metrnl levels was lower in CHF patients when compared with controls [201.31 (184.95\u2013261.16) pg\/mL vs. 168.68 (103.15\u2013197.54) pg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]. Patients with the lowest levels of Metrnl had higher N\u2010terminal pro brain natriuretic peptide (NT\u2010proBNP) levels but lower left ventricular eject fraction (LVEF) and estimated glomerular filtration rate (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Lower serum Metrnl was associated with a higher risk of &gt;5% weight loss from baseline to 12\u00a0months [odds ratio\u00a0=\u00a06.13, 95% confidence interval (CI)\u00a0=\u00a02.57\u201314.62 per log decrease; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]. Serum Metrnl levels were decreased as LVEF decreased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and were positively correlated with LVEF (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.267, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) but negatively correlated with NT\u2010proBNP levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.257, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Cox regression analysis suggested that lower serum Metrnl was associated with higher cardiovascular mortality [hazard ratio (HR)\u00a0=\u00a06.71, 95% CI\u00a0=\u00a03.41\u201313.18 per log decrease; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001], CHF rehospitalization (HR\u00a0=\u00a03.07, 95% CI\u00a0=\u00a01.82\u20135.17 per log decrease; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and the combined major adverse cardiac event(s) (MACEs) (HR\u00a0=\u00a05.38, 95% CI\u00a0=\u00a03.51\u20138.25 per log decrease; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The Kaplan\u2013Meier survival curves showed that low concentration of Metrnl was a prognostic indicator of MACEs in patients with CHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that lower serum Metrnl level is correlated with weight loss and the severity of cardiac dysfunction in elderly patients with CHF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12865","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T06:19:53Z","timestamp":1637561993000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Serum Meteorin\u2010like is associated with weight loss in the elderly patients with chronic heart failure"],"prefix":"10.1002","volume":"13","author":[{"given":"Juan","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Cardiology Nantong Hospital of Traditional Chinese Medicine  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Sir Run Run Hospital, Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory for Aging &amp; Disease Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Sir Run Run Hospital, Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory for Aging &amp; Disease Nanjing Medical University  Nanjing 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