{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:52:27Z","timestamp":1790632347628,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T00:00:00Z","timestamp":1639267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The strength, assistance walking, rise from a chair, climb stairs, and falls (SARC\u2010F) questionnaire is a well\u2010established instrument for screening of sarcopenia and sarcopenia\u2010related functional impairments. As it is based on self\u2010reporting, its use precludes patients who are unable to answer the questionnaire as a consequence of severe acute diseases or cognitive impairment. Therefore, we aimed to validate a proxy\u2010reported version of the SARC\u2010F for both ad\u2010hoc as well as retrospective screening for severe sarcopenia\u2010related functional impairments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged \u226560\u00a0years completed the SARC\u2010F and performed the short physical performance battery (SPPB) at baseline (T1). Proxies in Cohort A gave a simultaneous assessment of the patients' functional status with the proxy\u2010reported SARC\u2010F at T1 and again, retrospectively, after 3\u00a0months (T2). Proxies in Cohort B only completed the SARC\u2010F retrospectively at T2.<\/jats:p>\n                    <jats:p>The questionnaires' performances were assessed through sensitivity\/specificity analyses and receiver operating characteristic (ROC) curves. For non\u2010inferiority analyses, results of both the patient\u2010reported and proxy\u2010reported SARC\u2010F were correlated with the SPPB total score as well as the results of the chair\u2010rise test subcategory; the respective correlation coefficients were tested against each other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and four patients and 135 proxies participated. Using a SPPB score\u00a0&lt;\u00a09 points as the reference standard, the proxy\u2010reported SARC\u2010F identified patients at high risk for sarcopenia\u2010related functional impairment with a sensitivity of 0.81 (ad\u2010hoc), 0.88 (retrospective Cohort A), and 0.87 (retrospective Cohort B) as well as a specificity of 0.89 (ad\u2010hoc), 0.78 (retrospective Cohort A), and 0.64 (retrospective Cohort B). Areas under the ROC curves were\u00a0\u2265\u00a00.9 for the ad\u2010hoc proxy\u2010reported SARC\u2010F and the retrospective proxy\u2010reported SARC\u2010F in both cohorts. The proxy\u2010reported SARC\u2010F showed a non\u2010inferior correlation with the SPPB compared with the patient\u2010reported SARC\u2010F for ad\u2010hoc (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0&lt;0.001) as well as retrospective screening for severe sarcopenia\u2010related functional impairment in both Cohorts A (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007) and B (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Proxy\u2010reported SARC\u2010F is a valid instrument for both ad\u2010hoc as well as retrospective screening for sarcopenia\u2010related functional impairment and could become the standard tool for evaluating this risk in older adults with severe acute disease, for example, in patients with quickly evolving haematological conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.12871","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T02:11:55Z","timestamp":1639361515000},"page":"264-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Validation of a proxy\u2010reported SARC\u2010F questionnaire for current and retrospective screening of sarcopenia\u2010related functional impairments"],"prefix":"10.1002","volume":"13","author":[{"given":"Johannes","family":"Maurus","sequence":"first","affiliation":[{"name":"Department of Medicine V \u2013 Haematology, Oncology and Rheumatology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Clinic for Urology University Hospital Augsburg  Augsburg 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Roth","sequence":"additional","affiliation":[{"name":"Center of Geriatric Medicine Heidelberg University, AGAPLESION Bethanien Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Medicine V \u2013 Haematology, Oncology and Rheumatology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Department of Medicine V \u2013 Haematology, Oncology and Rheumatology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes Martin","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Medicine V \u2013 Haematology, Oncology and Rheumatology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Micol","sequence":"additional","affiliation":[{"name":"Center of Geriatric Medicine Heidelberg University, AGAPLESION Bethanien Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hauer","sequence":"additional","affiliation":[{"name":"Center of Geriatric Medicine Heidelberg University, AGAPLESION Bethanien Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"M\u00fcller\u2010Tidow","sequence":"additional","affiliation":[{"name":"Department of Medicine V \u2013 Haematology, Oncology and Rheumatology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen M.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Center of Geriatric Medicine Heidelberg University, AGAPLESION Bethanien Hospital Heidelberg  Heidelberg Germany"},{"name":"Network Aging Research (NAR) Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Medicine V \u2013 Haematology, Oncology and Rheumatology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-3616","authenticated-orcid":false,"given":"Nina Rosa","family":"Neuendorff","sequence":"additional","affiliation":[{"name":"Department of Medicine V \u2013 Haematology, Oncology and Rheumatology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Clinic for Haematology and Stem\u2010Cell Transplantation University Hospital Essen  Essen 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