{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:38:16Z","timestamp":1784302696635,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of sarcopenia is increased with declining renal function. Elevated serum indoxyl sulfate levels are associated with poor skeletal muscle conditions. We aimed to determine the effects of AST\u2010120, the oral adsorbent of indoxyl sulfate, on sarcopenia and sarcopenia\u2010associated factors in chronic kidney disease patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 48\u00a0week, randomized controlled, parallel group, open\u2010label, multicentre trial (<jats:italic>n<\/jats:italic>\u00a0=\u00a0150). The participants were randomly assigned in a 1:1 ratio to the control (CON) and AST\u2010120 (Renamezin\u00ae, REN) groups. Outcome measurements were performed at baseline and every 24\u00a0weeks for 48\u00a0weeks. The primary outcome was gait speed difference \u22650.1\u00a0m\/s between the two groups, and secondary outcomes included hand grip strength, muscle mass, and health\u2010related quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A difference of gait speed \u22650.1\u00a0m\/s was not observed during the study period. The mean dynamic\u2010start gait speed in the REN group increased from baseline to 48\u00a0weeks (1.04\u00a0\u00b1\u00a00.31 to 1.08\u00a0\u00b1\u00a00.32\u00a0m\/s, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.019). The static\u2010start gait speed changed by \u22120.024 and 0.04\u00a0m\/s (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049) in the CON and REN groups over 48\u00a0weeks, respectively. Hand grip strength decreased during the first 24\u00a0weeks and did not significantly change over the next 24\u00a0weeks in either group. The proportion of low muscle mass or sarcopenia at baseline was larger in the REN group than in the CON group, but the difference attenuated over the study period [low muscle mass and sarcopenia in the CON and REN groups at baseline, 4.0% vs. 18.9% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and 2.7% vs. 13.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017); at 24\u00a0weeks, 2.9% vs. 13.6% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021) and 1.4% vs. 10.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.029); and at 48\u00a0weeks, 7.6% vs. 12.9% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.319) and 4.5% vs. 8.1% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.482), respectively]. Bodily pain, vitality, symptoms\/problems, and cognitive function in the REN group improved, while the quality of social interactions and the kidney disease effects in the CON group aggravated from baseline to 48\u00a0weeks. Interaction between time and group was evident only in symptoms\/problems, cognitive function, and kidney disease effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of AST\u2010120 to standard treatment in chronic kidney disease patients did not make a significant difference in gait speed, although AST\u2010120 modestly had beneficial effects on gait speed change and quality of life and showed the potential to improve sarcopenia. (clinicaltrials.gov: NCT03788252).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12874","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T07:57:37Z","timestamp":1638604657000},"page":"397-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of AST\u2010120 on muscle health and quality of life in chronic kidney disease patients: results of RECOVERY study"],"prefix":"10.1002","volume":"13","author":[{"given":"Ran\u2010hui","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Hui","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yeungnam University College of Medicine  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Yeun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Hangang Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Suk","family":"An","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dong\u2010A University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University Hospital, Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, CHA Gumi Medical Center CHA University  Gumi Republic of 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