{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:24:45Z","timestamp":1753885485983,"version":"3.40.5"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brown adipose tissue (BAT) has been primarily researched as a potential target for mitigating obesity. However, the physiological significance of BAT in relation to cachexia remains poorly understood. The objective of this study was to investigate the putative contribution of BAT on different components of energy metabolism in emphysematous chronic obstructive pulmonary disease (COPD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty COPD patients (mean\u00a0\u00b1\u00a0SD age 62\u00a0\u00b1\u00a06, 50% female, median [range] BMI 22.4 [15.1\u201332.5] kg\/m<jats:sup>2<\/jats:sup> and 85% low FFMI) were studied. Basal metabolic rate (BMR) was assessed by ventilated hood, total daily energy expenditure (TDEE) by doubly labelled water and physical activity by triaxial accelerometry. BMR was adjusted for fat\u2010free mass (FFM) as assessed by deuterium dilution. Analysis of BAT and WAT was conducted in a subset of ten patients and six age\u2010matched, gender\u2010matched and BMI\u2010matched healthy controls. BAT glucose uptake was assessed by means of cold\u2010stimulated integrated [18F]FDG positron\u2010emission tomography and magnetic resonance imaging. WAT was collected from subcutaneous abdominal biopsies to analyse metabolic and inflammatory gene expression levels. Lung function was assessed by spirometry and body plethysmography and systemic inflammation by high sensitivity C\u2010reactive protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean TDEE was 2209\u00a0\u00b1\u00a0394\u00a0kcal\/day, and mean BMR was 1449\u00a0\u00b1\u00a0214\u00a0kcal\/day corresponding to 120% of predicted. FFM\u2010adjusted BMR did not correlate with lung function or C\u2010reactive protein. Upon cooling, energy expenditure increased, resulting in a non\u2010shivering thermogenesis of (median [range]) 20.1% [3.3\u201341.3] in patients and controls. Mean BAT glucose uptake was comparable between COPD and controls (1.5 [0.1\u20136.2] vs. 1.1 [0.7\u20133.9]). In addition, no correlation was found between BMR adjusted for FFM and BAT activity or between cold\u2010induced non\u2010shivering energy expenditure and BAT activity. Gene expression levels of the brown adipocyte or beige markers were also comparable between the groups. No (serious) adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although COPD patients were hypermetabolic at rest, no correlation was found between BMR or TDEE and BAT activity. Furthermore, both BAT activity and gene expression levels of the brown adipocyte or beige markers were comparable between COPD patients and controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12881","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T08:42:53Z","timestamp":1644914573000},"page":"1329-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Brown adipose tissue activation is not related to hypermetabolism in emphysematous chronic obstructive pulmonary disease patients"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-3324","authenticated-orcid":false,"given":"Karin J.C.","family":"Sanders","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre  Maastricht The 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Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Plasqui","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco C.J.M.","family":"Kelders","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera B.","family":"Schrauwen\u2010Hinderling","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre  Maastricht The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, NUTRIM School for Nutrition and Translational Research in Maastricht Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Bucerius","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine and CARIM School for Cardiovascular Research Institute Maastricht Maastricht University Medical Centre  Maastricht The Netherlands"},{"name":"Department of Nuclear Medicine University Medicine G\u00f6ttingen, Georg\u2010August\u2010University G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Marie C.","family":"Dingemans","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix 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