{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:50:26Z","timestamp":1773219026577,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Quadriceps tendon ruptures (QTRs) are rare but debilitating injuries, often associated with chronic metabolic conditions or long\u2010term steroid treatment. While the surgical treatment for acute QTRs is described thoroughly, no common strategy exists for the often frustrating treatment of chronic, reoccurring QTRs. The pro\u2010angiogenic and immunomodulatory properties of placenta\u2010derived adherent mesenchymal stromal\u2010like (PLX\u2010PAD) cells have been described to protect musculoskeletal tissues from inflammation and catabolic cytokine migration, yet little is known about the regenerative potential of PLX\u2010PAD cells in repetitively damaged tendon tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We report the case of an 80\u2010year\u2010old male patient with a chronic three\u2010time QTR of his right knee. The quadriceps tendon was reconstructed applying a conventional suture anchor repair procedure combined with a synthetic mesh augmentation and additional intramuscular and intratendineous PLX\u2010PAD cell injections as an individualized treatment approach. No adverse events were reported, and excellent radiological and functional outcomes with a passive range of motion of 0\/0\/120\u00b0 knee extension\u2010flexion were observed at the 12 month follow\u2010up. Gait analysis confirmed restoration of joint motion, including gait speed, deficit in step length, and knee extensor muscle strength (pre\u2010surgery: 0.98\u00a0m\/s, 40\u00a0cm, 42.4\u00a0\u00b1\u00a012.4\u00a0N; 9\u00a0months post\u2010surgery: 1.07\u00a0m\/s, 0\u00a0cm, 10.4\u00a0\u00b1\u00a018.9\u00a0N) as well as hyperextension throughout stance and late swing phases (pre\u2010surgery: \u221211.2\u00a0\u00b1\u00a00.9\u00b0; 9\u00a0months post\u2010surgery: \u22122.7\u00a0\u00b1\u00a01.6\u00b0). Postoperative lymphocyte and cytokine analyses from the patient's peripheral blood serum suggested a systemic short\u2010term immunoregulatory reaction with postoperatively increased interleukin (IL)\u20106 (pre\u2010surgery: 0.79\u00a0pg\/mL; day 1: 139.97\u00a0pg\/mL; day 5: 5.58\u00a0pg\/mL; 9\u00a0months: 1.76\u00a0pg\/mL) and IL\u201010 (pre\u2010surgery: 0.9\u00a0pg\/mL; day 1: 1.21\u00a0pg\/ mL; day 5: 0.3\u00a0pg\/mL; 9\u00a0months: 0.34\u00a0pg\/mL) levels that decreased again over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Herein, we demonstrate a successfully treated chronic QTR with a synergistic surgical and biological reconstructive treatment approach. This local add\u2010on treatment with PLX\u2010PAD cells may be considered in specific cases of chronic QTRs, not susceptible to traditional suture anchor procedures and which exhibit a high risk of treatment failure. Further scientific engagement is warranted to explore underlying immunomodulatory mechanisms of action behind PLX\u2010PAD cell treatment for tendon injuries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12894","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T11:21:20Z","timestamp":1641381680000},"page":"434-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intramuscular and intratendinous placenta\u2010derived mesenchymal stromal\u2010like cell treatment of a chronic quadriceps tendon rupture"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-7384","authenticated-orcid":false,"given":"Tazio","family":"Maleitzke","sequence":"first","affiliation":[{"name":"Center for Musculoskeletal Surgery Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Julius Wolff Institute Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"BIH Charit\u00e9 Clinician Scientist Program Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-4375","authenticated-orcid":false,"given":"Petra","family":"Reinke","sequence":"additional","affiliation":[{"name":"Department of Nephrology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Berlin Institute of Health Center for Regenerative Therapies Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-5689","authenticated-orcid":false,"given":"Alison N.","family":"Agres","sequence":"additional","affiliation":[{"name":"Julius Wolff Institute Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-3720","authenticated-orcid":false,"given":"S\u00f3nia A.","family":"Alves","sequence":"additional","affiliation":[{"name":"Julius Wolff Institute Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-8505","authenticated-orcid":false,"given":"Levent","family":"Aky\u00fcz","sequence":"additional","affiliation":[{"name":"Julius Wolff Institute Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-1721","authenticated-orcid":false,"given":"Florian N.","family":"Fleckenstein","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4611-9301","authenticated-orcid":false,"given":"Anna","family":"Bichmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-7460","authenticated-orcid":false,"given":"Racheli","family":"Ofir","sequence":"additional","affiliation":[{"name":"Pluristem Therapeutics Inc.  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