{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:57:51Z","timestamp":1792403871037,"version":"4.4.0"},"reference-count":110,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18AIREA33960528"],"award-info":[{"award-number":["18AIREA33960528"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010202","name":"U.S. Army Research Institute of Environmental Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sarcopenia, or the age\u2010related loss of skeletal muscle mass and function, is an increasingly prevalent condition that contributes to reduced quality of life, morbidity, and mortality in older adults. Older adults display blunted anabolic responses to otherwise anabolic stimuli\u2014a phenomenon that has been termed anabolic resistance (AR)\u2014which is likely a casual factor in sarcopenia development. AR is multifaceted, but historically much of the mechanistic focus has been on signalling impairments, and less focus has been placed on the role of the vasculature in postprandial protein kinetics. The vascular endothelium plays an indispensable role in regulating vascular tone and blood flow, and age\u2010related impairments in vascular health may impede nutrient\u2010stimulated vasodilation and subsequently the ability to deliver nutrients (e.g. amino acids) to skeletal muscle. Although the majority of data has been obtained studying younger adults, the relatively limited data on the effect of blood flow on protein kinetics in older adults suggest that vasodilatory function, especially of the microvasculature, strongly influences the muscle protein synthetic response to amino acid feedings. In this narrative review, we examine evidence of AR in older adults following amino acid and mixed meal consumption, examine the evidence linking vascular dysfunction and insulin resistance to age\u2010related AR, review the influence of nitric oxide and endothelin\u20101 on age\u2010related vascular dysfunction as it relates to AR, briefly review the potential causal role of arterial stiffness in promoting skeletal muscle microvascular dysfunction and AR, and provide a brief overview and future considerations for research examining age\u2010related AR.<\/jats:p>","DOI":"10.1002\/jcsm.12898","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T01:19:13Z","timestamp":1640308753000},"page":"114-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The contributory role of vascular health in age\u2010related anabolic resistance"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-9163","authenticated-orcid":false,"given":"Nile F.","family":"Banks","sequence":"first","affiliation":[{"name":"Integrative Laboratory of Applied Physiology and Lifestyle Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Integrative Laboratory of Applied Physiology and Lifestyle Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-5037","authenticated-orcid":false,"given":"David D.","family":"Church","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Aging and Longevity, College of Medicine University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arny A.","family":"Ferrando","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Aging and Longevity, College of Medicine University of Arkansas for Medical Sciences  Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-3414","authenticated-orcid":false,"given":"Nathaniel D.M.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Integrative Laboratory of Applied Physiology and Lifestyle Medicine University of Iowa  Iowa City IA USA"},{"name":"Abboud Cardiovascular Research Center University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3258-72-45"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.04.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24505"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.01.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130740"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-017-0302-x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt149"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/0361073X.2015.1001648"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009520"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1059-y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00061.2017"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12238"},{"key":"e_1_2_10_14_1","first-page":"93","article-title":"Economic impact of hospitalizations in US adults with sarcopenia","volume":"8","author":"Goates S","year":"2019","journal-title":"J Frailty Aging"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30677-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2640fje"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.10.1206"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e318292f3d5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.068841"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00271.2005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4607fje"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.311378"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13202"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.020800"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2696"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0415"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.12.4481"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000233799.62153.19"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009191"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-018-1009-y"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318223b037"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.264.5.E693"},{"key":"e_1_2_10_34_1","first-page":"E790","article-title":"Effects of aging on in vivo synthesis of skeletal muscle myosin heavy\u2010chain and sarcoplasmic protein in humans","volume":"273","author":"Balagopal P","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14633"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.5.1065"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00488.2005"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-013-9522-2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3970"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00408.2002"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.8.820"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00012.2007"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.05.017"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12395"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.6.1418"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2682"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-0523-x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa025"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt015"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00289.2013"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1566"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(05)80242-3"},{"key":"e_1_2_10_53_1","first-page":"E911","article-title":"Effect of hyperinsulinemia on whole body and skeletal muscle leucine carbon kinetics in humans","volume":"262","author":"Heslin MJ","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.5.949"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1430-8"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-013-0099-5"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.4.817"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.009"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.149"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270129"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01663.x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130708"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1073"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305447"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191609"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110723"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00440.2013"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.119"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00122.2016"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04368-8"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.09.031"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401004010302"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100476"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91013-1"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.3.519"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2017.05.005"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0030-z"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2017"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00994-X"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131515.03336.f8"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03575"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048892.83521.58"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls242"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006431309841"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9797"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0880509"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1506"},{"key":"e_1_2_10_88_1","first-page":"852","article-title":"Enhanced endothelin\u20101\u2010mediated leg vascular tone in healthy older subjects","volume":"2007","author":"Thijssen DH","year":"1985","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_89_1","first-page":"210","article-title":"Endothelin. Immunohistologic localization in aorta and biosynthesis by cultured human aortic endothelial cells","volume":"67","author":"Tokunaga O","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.088294"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.5.1120"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0763-y"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.8.2060"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.12.3517"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.017"},{"key":"e_1_2_10_96_1","first-page":"1652","article-title":"Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end\u2010organ damage","volume":"2008","author":"Mitchell GF","year":"1985","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00041"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160549"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281fbd15e"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009515"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.551168"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1502"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1772-b"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx203"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2063179"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11041509"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.111220"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200205000-00014"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001854"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.09.017"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12898","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T23:57:45Z","timestamp":1692489465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":110,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jcsm.12898"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12898","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,23]]},"assertion":[{"value":"2021-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}