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We examined associations of device\u2010measured sleep, SB and PA, and time reallocations among them, with GDF\u201015 in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from 2245 older adults participating in the Seniors\u2010ENRICA\u20102 study. Wrist\u2010worn accelerometers were employed to ascertain total time in sleep, SB, light PA (LPA) and moderate\u2010to vigorous PA (MVPA). Associations between these activities and serum GDF\u201015 levels were analysed using linear regression, including isotemporal substitution models for time reallocations among activities, and adjusted for potential confounders. Analyses were conducted separately in two groups (less active and more active individuals) according to the median total PA time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the less active participants, 30\u00a0min\/day more of MVPA were related to lower levels of GDF\u201015 when replacing sleep (fully adjusted mean percentage differences [95% confidence interval] in GDF\u201015 of \u22129.2% [\u221213.2, \u22125.0]), SB (\u22129.8% [\u221213.6, \u22125.8]) and LPA (\u22125.8% [\u221211.1, \u22120.3]), whereas 30\u00a0min\/day more of LPA were related to lower GDF\u201015 when replacing both sleep (\u22123.6% [\u22126.1, \u22121.0]) and SB (\u22124.2% [\u22126.7, \u22121.7]). In the more active participants, 30\u00a0min\/day more of MVPA were also associated with lower GDF\u201015 when replacing sleep (\u22122.9% [\u22125.3, \u22120.3]), SB (\u22122.4% [\u22124.6, \u22120.2]) and LPA (\u22123.5% [\u22126.6, \u22120.3]), but no associations were found for more time in LPA. Spending more time in SB was associated with higher GDF\u201015 levels only among those less active (1.9% [0.9, 2.9] per 30\u00a0min\/day increment). Sleep time did not appear to be associated with GDF\u201015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The MVPA was inversely associated with GDF\u201015, with stronger associations at lower PA volumes. Also, more LPA and less SB time were linked to lower GDF\u201015 in the less active individuals. This suggests that simply moving more and sitting less may reduce chronic disease burden in older adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12924","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T03:29:16Z","timestamp":1644290956000},"page":"1003-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Associations of device\u2010measured sleep, sedentariness and physical activity with growth differentiation factor 15 in older adults"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-9533","authenticated-orcid":false,"given":"Rosario","family":"Ortol\u00e1","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"Cardiovascular and Nutritional Epidemiology Group IdiPAZ (La Paz University Hospital\u2014Universidad Aut\u00f3noma de Madrid)  Madrid Spain"},{"name":"CIBER of Epidemiology and Public Health (CIBERESP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Garc\u00eda\u2010Esquinas","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"Cardiovascular and Nutritional Epidemiology Group IdiPAZ (La Paz University Hospital\u2014Universidad Aut\u00f3noma de Madrid)  Madrid Spain"},{"name":"CIBER of Epidemiology and Public Health (CIBERESP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bu\u00f1o\u2010Soto","sequence":"additional","affiliation":[{"name":"Cardiovascular and Nutritional Epidemiology Group IdiPAZ (La Paz University Hospital\u2014Universidad Aut\u00f3noma de Madrid)  Madrid Spain"},{"name":"Department of Laboratory Medicine La Paz University Hospital\u2010IdiPaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Cabanas\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"IMDEA Food Institute. CEI UAM\u00a0+\u00a0CSIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mart\u00ednez\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"Cardiovascular and Nutritional Epidemiology Group IdiPAZ (La Paz University Hospital\u2014Universidad Aut\u00f3noma de Madrid)  Madrid Spain"},{"name":"CIBER of Epidemiology and Public Health (CIBERESP)  Madrid Spain"},{"name":"IMDEA Food Institute. 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