{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:23:03Z","timestamp":1792092183327,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["PI17\/01814"],"award-info":[{"award-number":["PI17\/01814"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016120","name":"Departamento de Salud, Gobierno de Navarra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairment and dementia. We assessed the effects of the Vivifrail exercise intervention for functional capacity, cognition, and well\u2010being status in community\u2010dwelling older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multicentre randomized controlled trial conducted in three tertiary hospitals in Spain, a total of 188 older patients with mild cognitive impairment or mild dementia (aged &gt;75\u00a0years) were randomly assigned to an exercise intervention (<jats:italic>n<\/jats:italic>\u00a0=\u00a088) or a usual\u2010care, control (<jats:italic>n<\/jats:italic>\u00a0=\u00a0100) group. The intervention was based on the Vivifrail tailored multicomponent exercise programme, which included resistance, balance, flexibility (3\u00a0days\/week), and gait\u2010retraining exercises (5\u00a0days\/week) and was performed for three consecutive months (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/vivifrail.com\">http:\/\/vivifrail.com<\/jats:ext-link>). The usual\u2010care group received habitual outpatient care. The main endpoint was change in functional capacity from baseline to 1 and 3\u00a0months, assessed with the Short Physical Performance Battery (SPPB). Secondary endpoints were changes in cognitive function and handgrip strength after 1 and 3\u00a0months, and well\u2010being status, falls, hospital admission rate, visits to the emergency department, and mortality after 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Vivifrail exercise programme provided significant benefits in functional capacity over usual\u2010care. The mean adherence to the exercise sessions was 79% in the first month and 68% in the following 2\u00a0months. The intervention group showed a mean increase (over the control group) of 0.86 points on the SPPB scale (95% confidence interval [CI] 0.32, 1.41 points; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) after 1\u00a0month of intervention and 1.40 points (95% CI 0.82, 1.98 points; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) after 3\u00a0months. Participants in the usual\u2010care group showed no significant benefit in functional capacity (mean change of \u22120.17 points [95% CI \u22120.54, 0.19 points] after 1\u00a0month and \u22120.33 points [95% CI \u22120.70, 0.04 points] after 3\u00a0months), whereas the exercise intervention reversed this trend (0.69 points [95% CI 0.29, 1.09 points] after 1\u00a0month and 1.07 points [95% CI 0.63, 1.51 points] after 3\u00a0months). Exercise group also obtained significant benefits in cognitive function, muscle function, and depression after 3\u00a0months over control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). No between\u2010group differences were obtained in other secondary endpoints (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Vivifrail exercise training programme is an effective and safe therapy for improving functional capacity in community\u2010dwelling frail\/prefrail older patients with mild cognitive impairment or mild dementia and also seems to have beneficial effect on cognition, muscle function, and mood status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.12925","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T06:39:50Z","timestamp":1644647990000},"page":"884-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":171,"title":["Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial"],"prefix":"10.1002","volume":"13","author":[{"given":"\u00c1lvaro","family":"Casas\u2010Herrero","sequence":"first","affiliation":[{"name":"Geriatric Department Hospital Universitario de Navarra (HUN)  Pamplona Spain"},{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel L.","family":"S\u00e1ez de Asteasu","sequence":"additional","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA  Pamplona Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Ant\u00f3n\u2010Rodrigo","sequence":"additional","affiliation":[{"name":"Geriatric Department Ricardo Bermingham Hospital, Matia Fundazioa  San Sebastian Spain"},{"name":"Grupo de Investigacion en Atenci\u00f3n Primaria Biodonostia Institute of Health Research  San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"S\u00e1nchez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Gerontopole of Toulouse, Institute of Ageing Toulouse University Hospital (CHU Toulouse)  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero\u2010Odasso","sequence":"additional","affiliation":[{"name":"Gait and Brain Lab, Parkwood Institute Lawson Health Research Institute  London Ontario Canada"},{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine &amp; 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