{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:31:32Z","timestamp":1791772292619,"version":"4.3.4"},"reference-count":85,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Low skeletal muscle mass is known to be associated with poor morbidity and mortality outcomes in cancer, but evidence of its impact on health\u2010related quality of life (HRQOL) is less established. This systematic review and meta\u2010analysis was performed to investigate the relationship between skeletal muscle mass and HRQOL in adults with cancer. Five databases (Ovid MEDLINE, Embase via Ovid, CINAHL plus, Scopus, and PsycInfo) were systematically searched from 1 January 2007 until 2 September 2020. Studies reporting on the association between measures of skeletal muscle (mass and\/or radiodensity) derived from analysis of computed tomography imaging, and a validated measure of HRQOL in adults with cancer, were considered for inclusion. Studies classifying skeletal muscle mass as a categorical variable (low or normal) were combined in a meta\u2010analysis to investigate cross\u2010sectional association with HRQOL. Studies reporting skeletal muscle as a continuous variable were qualitatively synthesized. A total of 14 studies involving 2776 participants were eligible for inclusion. Skeletal muscle mass classified as low or normal was used to dichotomize participants in 10 studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01375). Five different cut points were used for classification across the 10 studies, with low muscle mass attributed to 58% of participants. Low muscle mass was associated with poorer global HRQOL scores [\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0985 from seven studies, standardized mean difference \u22120.27, 95% confidence interval (CI) \u22120.40 to \u22120.14,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001], and poorer physical functioning domain HRQOL scores (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0507 from five studies, standardized mean difference \u22120.40, 95% CI \u22120.74 to \u22120.05,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.02), but not social, role, emotional, or cognitive functioning domain scores (all\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a00.05). Five studies examined the cross\u2010sectional relationship between HRQOL and skeletal muscle mass as a continuous variable and found little evidence of an association unless non\u2010linear analysis was used. Two studies investigated the relationship between longitudinal changes in both skeletal muscle and HRQOL, reporting that an association exists across several HRQOL domains. Low muscle mass may be associated with lower global and physical functioning HRQOL scores in adults with cancer. The interpretation of this relationship is limited by the varied classification of low muscle mass between studies. There is a need for prospective, longitudinal studies examining the interplay between skeletal muscle mass and HRQOL over time, and data should be made accessible to enable reanalysis according to different cut points. Further research is needed to elucidate the causal pathways between these outcomes.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.12928","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T21:54:52Z","timestamp":1644789292000},"page":"839-857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Association between skeletal muscle mass and quality of life in adults with cancer: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-7169","authenticated-orcid":false,"given":"Lauren","family":"Hanna","sequence":"first","affiliation":[{"name":"Department of Nutrition, Dietetics and Food Monash University Clayton VIC Australia"},{"name":"Department of Nutrition and Dietetics, Monash Medical Centre Monash Health Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-6660","authenticated-orcid":false,"given":"Kay","family":"Nguo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics and Food Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-3050","authenticated-orcid":false,"given":"Kate","family":"Furness","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Monash Medical Centre Monash Health Clayton VIC Australia"},{"name":"Department of Physiotherapy, School of Primary and Allied Health Care Monash University Frankston VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-1919","authenticated-orcid":false,"given":"Judi","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics and Food Monash University Clayton VIC Australia"},{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences Deakin University Geelong VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-7756","authenticated-orcid":false,"given":"Catherine E.","family":"Huggins","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Dietetics and Food Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2722"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3902-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.01.075"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.030"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Preoperative sarcopenia is a predictor of poor prognosis of esophageal cancer after esophagectomy: a comprehensive systematic review and meta\u2010analysis","volume":"32","author":"Deng H\u2010Y","year":"2018","journal-title":"Dis Esophagus"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484950"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19687"},{"key":"e_1_2_8_10_1","first-page":"121","article-title":"Loss of muscle mass is a novel predictor of postoperative early recurrence in N2\u2010positive non\u2010small\u2010cell lung cancer","volume":"24","author":"Tsukioka T","year":"2018","journal-title":"Ann Torac Surg"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002398"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003164"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.350"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12529"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2418-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05352-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12224"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-075"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357909309024860"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62038-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.1.1.61"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jme.10.3.124"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc930"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910201)67:3 <844::AID-CNCR2820671416>3.0.CO;2-B"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-016-0389-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12206"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0255"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758834017698643"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3067"},{"key":"e_1_2_8_33_1","volume-title":"EndNote. EndNote X9 ed","author":"The EndNote Team","year":"2013"},{"key":"e_1_2_8_34_1","volume-title":"Covidence Systematic Review Software"},{"key":"e_1_2_8_35_1","volume-title":"Review Manager (RevMan). Version 5.4","year":"2014"},{"key":"e_1_2_8_36_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.2","author":"Higgins J","year":"2021"},{"key":"e_1_2_8_37_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_39_1","volume-title":"Evidence Analysis Manual: Steps in the Academy Evidence Analysis Process","year":"2016"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05624-3"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12200"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32824"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12562"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051247"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00195"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.05.045"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12312"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1595053"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2012.01327.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1539-z"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2076-x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.06.009"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00417-2"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00858-X"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.570"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.974"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006263818115"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900100101014"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880150603"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(98)00009-4"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4231-8"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278481"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606087"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90535-5"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.5.B209"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12856"},{"key":"e_1_2_8_70_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.32471\/exp-oncology.2312-8852.vol-41-no-2.13249","article-title":"The impact of maximal strength training on quality of life among women with breast cancer undergoing treatment","volume":"41","author":"Ce\u0161eiko R","year":"2019","journal-title":"Exp Oncol"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-2395-3-9"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2018.11.007"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1983.tb00704.x"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.04.019"},{"key":"e_1_2_8_75_1","article-title":"Nutrition, anabolism, and the wound healing process: an overview","volume":"9","author":"Demling RH","year":"2009","journal-title":"Eplasty"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.09.004"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-019-0691-9"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12267"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01034.x"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.12.003"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9384-z"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6395-8"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12180"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12525"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102017\u2010019117"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12501"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.12928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.12928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T07:10:22Z","timestamp":1700205022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.12928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,13]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/jcsm.12928"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.12928","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,13]]},"assertion":[{"value":"2021-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}